autism spectrum disorder, genetics & genomics, neuroscience

A mouse model of autism and postmortem brains of autistic individuals showed a lack of mature oligodendrocytes and less myelination than controls.

Signaling imbalance, driven by too much excitatory activity, may be a consequence of whatever brain changes lead to autism rather than a cause of the condition.

Changes in gene expression also hint at how the brains of people with ASD develop differently from those of other people.

The PsychENCODE project delves into the DNA, RNA, and protein changes related to brain development and neuropsychiatric disorders, but researchers caution it’s just a first step toward treatment.

Researchers parse genes linked with intellectual disability and autism from those tied to autism alone.

Researchers map learning-induced chromatin alterations in mouse brain cells, and find that many affect autism-associated genes.

As researchers sequence the DNA of thousands of kids with autism, dozens of genetic subgroups are emerging.