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SP140, an epigenetic reader protein mutated in a number of autoimmune disorders, is essential for macrophage function and preventing intestinal inflammation, scientists show. 

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image: Human Gut Microbe Transplant Alters Mouse Behavior

Human Gut Microbe Transplant Alters Mouse Behavior

By | March 1, 2017

Fecal transplants from humans with irritable bowel syndrome and anxiety into mice lead to similar symptoms and anxiety-like behavior in the rodents, researchers report.  

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image: Neonatal Gut Bacteria Might Promote Asthma

Neonatal Gut Bacteria Might Promote Asthma

By | September 12, 2016

Byproducts of gut microbes in some 1-month–old babies trigger inflammation that is linked to later asthma development, researchers find.

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image: One Antigen Receptor Induces Two T cell Types

One Antigen Receptor Induces Two T cell Types

By | August 26, 2016

Precursor T cells bearing the same antigen receptor adopt two different fates in mice.

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Three therapeutic doses administered during early life disturb the animals’ microbiomes and lead to enduring changes in the immune systems of non-obese diabetic mice, researchers report.

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image: Fecal Transplant Pill Fails Trial

Fecal Transplant Pill Fails Trial

By | August 1, 2016

Seres Therapeutics’s microbiome-targeting therapy for recurrent Clostridium difficile infection fails a Phase 2 clinical trial.

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image: Primates, Gut Microbes Evolved Together

Primates, Gut Microbes Evolved Together

By | July 21, 2016

Symbiotic gut bacteria evolved and diverged along with ape and human lineages, researchers find. 

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image: Stroke Alters Gut Microbiome, Impacting Recovery

Stroke Alters Gut Microbiome, Impacting Recovery

By | July 15, 2016

A bidirectional link between the brain and the gut can improve or worsen brain injury in mice, researchers report.

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image: Early-Life Microbiome

Early-Life Microbiome

By | June 16, 2016

Analyzing the gut microbiomes of children from birth through toddlerhood, researchers tie compositional changes to birth mode, infant diet, and antibiotic therapy.

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image: Gut Microbiota–Obesity Link Clarified

Gut Microbiota–Obesity Link Clarified

By | June 10, 2016

Changes in diet can cause gut microbes to produce acetate, which in turn stimulates insulin secretion and obesity in rodents, scientists show.

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