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Hands-On Power
Mike May | Nov 16, 2003 | 6 min read
Courtesy of Mike Curtis  TAG, YOU'RE SICK! School children learn about communicable diseases with handheld computers and a program called Cooties. In the 1830s, Charles Darwin used a pen and paper to document finches and other fauna and flora in the Galápagos Islands. For the next century and a half, most scientists relied on the same tools to take notes or collect data. Today, Dave Anderson, associate professor of biology at Wake Forest University, follows in Darwin's footsteps--
PCR Primed To Spur Chain Of Applications
Holly Ahern | Jun 25, 1995 | 10+ min read
What would you do if your research interests revolved around obtaining DNA from a bacterium preserved for millions of years in the gut of a bee stuck in amber, matching up a murderer to crime- scene blood half a century old, or cloning genes from a 1,000- year-old mummy? Most scientists would first consider PCR--the polymerase chain reaction--as a technique for approaching problems such as these. With PCR, minute quantities of nucleic acids can be amplified millions of times into sufficient qua
Revisiting Microarrays
Leonard Augenlicht | Oct 5, 2003 | 3 min read
Revisiting Microarrays Regarding the articles on microarrays,1-3 Pat Brown and the group at Stanford deserve great recognition for their technological innovations that led to widespread use of microarray analysis in biomedical research. However, the concept of computerized gene expression profiling, its reduction to practice, and enumeration of its potential in many areas of disease diagnosis, prognosis, drug sensitivity, and investigation of underlying mechanism has a much longer history.
Whole-Genome SNP Genotyping
Marilee Ogren | Jun 1, 2003 | 8 min read
Clockwise from top left: images courtesy of Affymetrix, Illumina, Sequenom and Illumina Take any two individuals, sequence and compare their genomic DNA, and you'll find that the vast majority (about 99.9%) of the sequences are identical. In the remaining 0.1% lie differences in disease susceptibility, environmental response, and drug metabolism. Researchers are understandably keen to dissect these variations, most of which take the form of single-nucleotide polymorphisms (SNPs). A SNP (pron
A Vaulted Mystery
Eufemia S. Putortì and Massimo P. Crippa | Aug 1, 2014 | 10+ min read
Nearly 30 years after the discovery of tiny barrel-shape structures called vaults, their natural functions remain elusive. Nevertheless, researchers are beginning to put these nanoparticles to work in biomedicine.
Senior Scientists Quit Europe
Silvia Sanides | Jun 1, 2003 | 7 min read
©Paul Barton, Corbis Rigid retirement policies are prompting scientists to flee Europe at the height of their professional lives to start second careers in the United States. Many of these researchers are still conducting experiments and are in no mood to slow down. But because nearly all European universities are government run, professors are left little choice when they reach mandatory retirement age, which in most countries is 65 years or even younger. Some scientists leaving for the
Jumping Genes A Buyers' Guide
Hillary Sussman | Jun 15, 2003 | 6 min read
Courtesy of Ivan Rayment  CAUGHT IN MID HOP: Structure of the Tn5 transposase/DNA complex No one believed Barbara McClintock in 1951 when she first described DNA that "jumped" from site to site within maize chromosomes, altering the expression of genes near the sites of integration. In due course, these transposable elements, or transposons, were found to be ubiquitous in nature, and 30 years later McClintock won the Nobel Prize. Today transposons have gone from molecular oddity to molec

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