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tag transcriptional regulation evolution cell molecular biology

DNA molecule.
Finding DNA Tags in AAV Stacks
Mariella Bodemeier Loayza Careaga, PhD | Mar 7, 2024 | 8 min read
Ten years ago, scientists put DNA barcodes in AAV vectors, creating an approach that simplified, expedited, and streamlined AAV screening. 
Microfluidics: Biology’s Liquid Revolution
Laura Tran, PhD | Feb 26, 2024 | 8 min read
Microfluidic systems redefined biology by providing platforms that handle small fluid volumes, catalyzing advancements in cellular and molecular studies.
Molecular Biology
The Scientist Staff | Nov 8, 1992 | 2 min read
L.D. Kerr, J.-I. Inoue, N. Davis, E. Link, et al., "The Rel- associated pp40 protein prevents DNA binding of Rel and NF-kB: relationship with IkBb and regulation by phosphorylation," Genes & Development, 5:1464-76, 1991. Lawrence Kerr (The Salk Institute, La Jolla, Calif.): "The regulation of protooncogene Rel, a transcription factor belonging to the family of NF-kB transcription factors, is important for the well-being of the cell because its altered form, v-rel, causes lymphoid leukemias. Wh
Microscopic image of a live amoeba.
Illuminating Specimens Through Live Cell Imaging
Charlene Lancaster, PhD | Mar 14, 2024 | 8 min read
Live cell imaging is a powerful microscopy technique employed by scientists to monitor molecular processes and cellular behavior in real time.
A person moving the hands of a vintage clock backwards.
Synthetic Circuits Reveal the Key to Rewinding the Cellular Clock
Charlene Lancaster, PhD | Mar 12, 2024 | 4 min read
Using a circuit-based system, scientists determined the ideal transcription factor levels to promote the successful reprogramming of fibroblasts into induced pluripotent stem cells.
A close up of a tick held in a pair of forceps, with Kevin Esvelt’s face out of focus in the background.
CRISPR Gene Drives and the Future of Evolution
Hannah Thomasy, PhD | Mar 15, 2024 | 10+ min read
Genetic engineering pioneer Kevin Esvelt’s work highlights biotechnology’s immense potential for good—but also for catastrophe.
Molecular Biology
The Scientist Staff | Mar 15, 1992 | 2 min read
B.F. Pugh, R. Tjian, "Mechanism of transcriptional activation by Sp1: evidence for coactivators," Cell, 61:1187-97, 1990. Franklin Pugh (Howard Hughes Medical Institute, University of California, Berkeley): "The story of eukaryotic transcriptional coactivators has provoked a new way of thinking about how sequence-specific activators communicate with the basal transcriptional machinery. "The prevailing thought prior to this work was that the TFIID component of this machine was a single protein
Molecular Biology
The Scientist Staff | Sep 1, 1991 | 1 min read
S. Ghosh, D. Baltimore, "Activation in vitro of NF-kB by phosphorylation of its inhibitor IkB," Nature, 344:678-82, 1990. Sankar Ghosh (Whitehead Institute for Biomedical Research, Cambridge, Mass.): "This paper brings together two areas of rapidly moving research: the role of protein phosphorylation and control of transcriptional regulation. The inhibitor IkB not only keeps the transcription factor NF-kB in the cytoplasm--away from DNA--but also directly prevents it from binding to DNA. By sh
Molecular Biology
The Scientist Staff | Jan 20, 1991 | 3 min read
C.K. Glass, S.M. Lipkin, O.V. Devary, M.G. Rosenfeld, "Positive and negative regulation of gene transcription by a retinoic acid-thyroid hormone receptor heterodimer," Cell, 59, 697-708, 17 November 1989. Christopher K. Glass (School of Medicine, University of California, San Diego, La Jolla): "Retinoic acid receptors appear to exert profound effects on vertebrate development by binding to target genes and altering the rates at which they are transcribed in response to retinoic acid. Because t
Molecular Biology
The Scientist Staff | Jan 6, 1991 | 1 min read
B. Berkhout, R.H. Silverman, K.-T. Jeang, "Tat trans-activates the human immunodeficiency virus through a nascent RNA target," Cell, 59, 273-82, 20 October 1989. Ben Berkhout (National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Md.): "The unique feature of this study was the use of RNA-refolding mutagenesis. Rearrangement of RNA structures was first described by Charles Yanofsky [Stanford University] to explain the process of transcriptional attenuation ["Transcription atten

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