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A close up of a tick held in a pair of forceps, with Kevin Esvelt’s face out of focus in the background.
CRISPR Gene Drives and the Future of Evolution
Hannah Thomasy, PhD | Mar 15, 2024 | 10+ min read
Genetic engineering pioneer Kevin Esvelt’s work highlights biotechnology’s immense potential for good—but also for catastrophe.
Different colored cartoon viruses entering holes in a cartoon of a human brain.
A Journey Into the Brain
Danielle Gerhard, PhD | Mar 22, 2024 | 10+ min read
With the help of directed evolution, scientists inch closer to developing viral vectors that can cross the human blood-brain barrier to deliver gene therapy.
The structure of a biological cell (macro)
The Long and Winding Road to Eukaryotic Cells
Amanda Heidt | Oct 17, 2022 | 10+ min read
Despite recent advances in the study of eukaryogenesis, much remains unresolved about the origin and evolution of the most complex domain of life.
A Y-shaped pink, blue, and light green antibody is in focus on a background of blurred pink and purple color, with other antibodies out of focus in the background.
Phage Display: Finding the One in a Million
Shelby Bradford, PhD | Dec 4, 2023 | 10+ min read
A combinatorial approach enabled high-throughput screening of protein libraries for desired target binding.
A rendering of a human brain in blue on a dark background with blue and white lines surrounding the brain to represent the construction of new connections in the brain.
Defying Dogma: Decentralized Translation in Neurons
Danielle Gerhard, PhD | Sep 8, 2023 | 10+ min read
To understand how memories are formed and maintained, neuroscientists travel far beyond the cell body in search of answers.
Top 7 papers in cell biology
Jef Akst | Dec 5, 2010 | 3 min read
Just in time for ASCB -- see the cell biology articles most highly ranked by F1000
Conceptual image showing molecules making up a brain shape
The Noncoding Regulators of the Brain
Christie Wilcox, PhD | Sep 12, 2022 | 10+ min read
Noncoding RNAs are proving to be critical players in the evolution of brain anatomy and cognitive complexity.
Illustration of a human and Neanderthal skull side by side.
Mutation Linked to Difference Between Human and Neanderthal Brains
Dan Robitzski | Sep 9, 2022 | 5 min read
A single amino acid substitution in a protein causes increased neuron production in the frontal lobes of humans compared to Neanderthals—a tiny difference that could have given our species a cognitive edge, researchers say.
a false color transmission electron microscope image of a neuronal cell body, with lysosomes colored dark green
Scientists Uncover Major Pathway Cells Use to Mend Leaky Lysosomes
Holly Barker, PhD | Oct 6, 2022 | 3 min read
Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say.
Artist’s rendition of a blue-green DNA double helix, viewed lengthwise from within one end.
Stem Cell Lines Riddled With Undetected Mutations
Dan Robitzski | Aug 12, 2022 | 4 min read
Most of the human induced pluripotent stem cells stored at major cell line repositories and used in research harbor thousands of DNA errors, a study finds, highlighting the need for improved quality control measures.

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