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tag bugs immunology evolution genetics genomics

Bugs as Drugs to Boost Cancer Therapy
Danielle Gerhard, PhD | Jan 18, 2024 | 7 min read
Bioengineered bacteria sneak past solid tumor defenses to guide CAR T cells’ attacks.
Fluorescent images of red cells showing high and low levels of infection in green
Parasite Drove Natural Selection in Amazonian Indigenous Groups
Natalia Mesa, PhD | Mar 13, 2023 | 4 min read
The findings could help researchers understand why some individuals are more vulnerable to deadly Chagas disease.
Artist’s rendering of various orange and pink colored bacteria
Q&A: What if Immune Cells Don’t Actually Detect Viruses and Bacteria?
Dan Robitzski | Feb 3, 2023 | 10+ min read
The Scientist spoke with Jonathan Kagan about his idea that immune cells respond to “errors” made by unsuccessful pathogens, not the pathogens themselves.
Ancient Mummies’ Lousy View of the Past
Ancient Mummies’ Lousy View of the Past
Nele Haelterman, PhD | Aug 25, 2022 | 3 min read
Researchers developed a method to study ancient human DNA preserved by head lice.
An illustration of green bacteria floating above neutral-colored intestinal villi
The Inside Guide: The Gut Microbiome’s Role in Host Evolution
Catherine Offord | Jul 1, 2021 | 10+ min read
Bacteria that live in the digestive tracts of animals may influence the adaptive trajectories of their hosts.
The Pangenome: Are Single Reference Genomes Dead?
Catherine Offord | Dec 1, 2016 | 10+ min read
Researchers are abandoning the concept of a list of genes sequenced from a single individual, instead aiming for a way to describe all the genetic variation within a species.
Top 10 Innovations 2021
2021 Top 10 Innovations
The Scientist | Dec 1, 2021 | 10+ min read
The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.
Outsmarting Influenza's Rapid Evolution
Philip Hunter | Jun 29, 2003 | 7 min read
Twice yearly, World Health Organization health officials meet to strategize against influenza, a malady that kills at least 250,000 people each year. In a chess match of sorts, they work to predict their opponent's next move, in this case by modifying vaccines to compensate for changes in the critical viral antigen hemagglutinin, which triggers the host's long-term immune memory. It takes several months to manufacture and distribute flu vaccines in sufficient quantities to inoculate vulnerabl
Targeting Antibiotic-Resistant Bacteria with CRISPR and Phages
Anna Azvolinsky | May 18, 2015 | 3 min read
Researchers develop a CRISPR-based, two-phage system that sensitizes resistant bacteria to antibiotics and selectively kills any remaining drug-resistant bugs. 
Birth of the Skin Microbiome
Anna Azvolinsky | Nov 17, 2015 | 3 min read
The immune system tolerates the colonization of commensal bacteria on the skin with the aid of regulatory T cells during the first few weeks of life, a mouse study shows.

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