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tag gene repressors culture disease medicine

bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Brain cell in purple on a black background. Arc mRNAs are labeled green and are mainly localized in the cell nucleus and in the dendrites.
Short-lived Molecules Support Long-term Memory 
Alejandra Manjarrez, PhD | Jun 6, 2023 | 3 min read
A gene essential for information storage in the brain engages an autoregulatory feedback loop to consolidate memory.
A rendering of a human brain in blue on a dark background with blue and white lines surrounding the brain to represent the construction of new connections in the brain.
Defying Dogma: Decentralized Translation in Neurons
Danielle Gerhard, PhD | Sep 8, 2023 | 10+ min read
To understand how memories are formed and maintained, neuroscientists travel far beyond the cell body in search of answers.
Bespoke Stem Cells for Brain Disease
Nsikan Akpan | Jan 14, 2013 | 3 min read
Scientists use virus-free gene therapy on patient-derived stem cells to repair spinal muscular atrophy in mice.
Unsilencing a Gene
Tia Ghose | Dec 21, 2011 | 3 min read
Scientists have found a way to reactivate a gene in mice that is silenced in a neurodevelopmental disorder called Angelman syndrome.
Progress In Medicine Unites Recipients Of 1997 Lasker Awards
Stephen Hoffert | Oct 26, 1997 | 8 min read
The Albert and Mary Lasker Foundation honored three medical researchers at an awards luncheon on September 26 in New York. According to a foundation official, the 1997 award winners represent the distinct approaches and scientific perspectives that must combine in the fight against disease. Victor A. McKusick, a professor of genetics at Johns Hopkins University, was given the Special Achievement in Medical Science Award; Mark S. Ptashne, the Ludwig Professor of Molecular Biology at the Mem
Variations on a Gene
Amy Francis | Jul 23, 2000 | 10+ min read
Photodisc Although President Bill Clinton surely had something in mind during his 2000 State of the Union address when he asked the nation to "celebrate our diversity," insights into human diversity at the molecular level are promising to speed drug discovery and revolutionize medicine to mark- edly improve human health. Individuals differ at one in 1,000 base pairs, which adds up to a whopping number of human genetic variations when applied to the roughly three billion base pairs of the human g
2022 Top 10 Innovations 
2022 Top 10 Innovations
The Scientist | Dec 12, 2022 | 10+ min read
This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.
Methylation: Gene Expression at the Right Place and Right Time
Nadia Halim | Dec 5, 1999 | 7 min read
Courtesy of Richard Roberts, New England BiolabsModel methylation reaction: Cytosine nucleotide (red) is flipped out of the DNA double helix by a methyltransferase (white), so it can be methylated. The end product after the methyl group has been transferred to the DNA is pictured in green. A tenuous link between DNA methylation and development has existed for several years. Now findings substantiate the connection. Researchers have found the first human diseases caused by defects in the DNA meth
Jumping Genes A Buyers' Guide
Hillary Sussman | Jun 15, 2003 | 6 min read
Courtesy of Ivan Rayment  CAUGHT IN MID HOP: Structure of the Tn5 transposase/DNA complex No one believed Barbara McClintock in 1951 when she first described DNA that "jumped" from site to site within maize chromosomes, altering the expression of genes near the sites of integration. In due course, these transposable elements, or transposons, were found to be ubiquitous in nature, and 30 years later McClintock won the Nobel Prize. Today transposons have gone from molecular oddity to molec

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