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tag gene repressors evolution disease medicine

Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
An illustration of green bacteria floating above neutral-colored intestinal villi
The Inside Guide: The Gut Microbiome’s Role in Host Evolution
Catherine Offord | Jul 1, 2021 | 10+ min read
Bacteria that live in the digestive tracts of animals may influence the adaptive trajectories of their hosts.
Methylation: Gene Expression at the Right Place and Right Time
Nadia Halim | Dec 5, 1999 | 7 min read
Courtesy of Richard Roberts, New England BiolabsModel methylation reaction: Cytosine nucleotide (red) is flipped out of the DNA double helix by a methyltransferase (white), so it can be methylated. The end product after the methyl group has been transferred to the DNA is pictured in green. A tenuous link between DNA methylation and development has existed for several years. Now findings substantiate the connection. Researchers have found the first human diseases caused by defects in the DNA meth
multicolor DNA sequencing gel
Genetic Mutations Can Be Benign or Cancerous—a New Method to Differentiate Between Them Could Lead to Better Treatments
Ryan Layer, The Conversation | May 27, 2022 | 5 min read
Tumors contain thousands of genetic changes, but only a few are actually cancer-causing. A quicker way to identify these driver mutations could lead to more targeted cancer treatments.
Cancer’s Escape Routes
Tia Ghose | Nov 29, 2011 | 5 min read
Scientists are beginning to discover myriad strategies tumors use to avoid attacks by anti-cancer drugs.
Chromosome 21 Reveals Sparse Gene Content
Ricki Lewis | Jun 11, 2000 | 8 min read
The unveiling of the DNA sequences of human chromosomes represents a new chapter in the unfolding story of genomics, but one with roots in the half-century-old field of cytogenetics. Chromosome-level looks can reveal the specific genes behind certain traits and disorders while providing information on genome organization. The diminutive chromosome 21--the smallest of the human contingent, despite its number as next to last--is the fourth to be described. Its debut in mid-May attracted attentio
Who Sleeps?
The Scientist and Jerome Siegel | Mar 1, 2016 | 10+ min read
Once believed to be unique to birds and mammals, sleep is found across the metazoan kingdom. Some animals, it seems, can’t live without it, though no one knows exactly why.
Collage of those featured in the article
Remembering Those We Lost in 2021
Lisa Winter | Dec 23, 2021 | 5 min read
As the year draws to a close, we look back on researchers we bid farewell to, and the contributions they made to their respective fields.
Top 10 Innovations 2021
2021 Top 10 Innovations
The Scientist | Dec 1, 2021 | 10+ min read
The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.
Inner Sanctum
Jeanne Mcadara | May 28, 2000 | 9 min read
Reagents for Nuclear Hormone Receptor Research Courtesy of Karo Bio ABEffect of an agonist (red spheres) or agonist/antagonist (green spheres) on the C terminal helix of the ligand binding domain of the estrogen receptor The survival of a living system depends on its ability to communicate with and respond to its surroundings. Even the simplest unicellular organism has surface molecules for assessing the external environment. Evolution of complex life forms required intricate methods for respo

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