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Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
A fruit bat in the hands of a researcher
How an Early Warning Radar Could Prevent Future Pandemics
Amos Zeeberg, Undark | Feb 27, 2023 | 8 min read
Metagenomic sequencing can help detect unknown pathogens, but its widespread use faces challenges.
The Proteasome: A Powerful Target for Manipulating Protein Levels
John Hines and Craig M. Crews | May 1, 2017 | 10+ min read
The proteasome’s ability to target and degrade specific proteins is proving useful to researchers studying protein function or developing treatments for diseases.
African Sleeping Sickness: A Recurring Epidemic
Ricki Lewis | May 12, 2002 | 5 min read
African trypanosomiasis is making an unwelcome comeback. But unlike other returning diseases, this one has a drug treatment—eflornithine—that disappeared from the market when it failed to cure cancer. Yet like Viagra's origin from a curious side effect in a clinical trial, so too was eflornithine reborn. "When it was discovered that it removes mustaches in women, it suddenly had a market: western women with mustaches," says Morten Rostrup, president of the international council for M
2009 Top 10 Innovations
The Scientist | Dec 1, 2009 | 10+ min read
#featureArticleHeadWrapper img { border:none; float:none; margin:5px 0; }#featureArticleContent p.comment { font-weight: bold; color: #333333; font-size: 11px; line-height: 15px; }span.judge_1 { color: #E93593; } span.judge_2 { color: #20BCED; } span.judge_3 { color: #C1CD2F; } span.judge_4 { color: #F69723; } The Scientist Top 10 Innovations: 2009 The ten most exciting tools to hit the life sciences this year. It’s b
Researchers Receiving MacArthur Fellowships Demonstrate 'Capacity To Make A Difference'
Bruce Anderson | Sep 14, 1997 | 6 min read
PRIZE WITH A PRICE: Science historian Peter Galison has taken some ribbing from his family since being named a MacArthur fellow. One could almost pity Peter Galison. A historian of science at Harvard University, Galison is one of seven members of the scientific community among the 23 recipients of this year's John D. and Catherine T. MacArthur Foundation Fellowships. The coveted five-year awards provide unrestricted support plus health insurance to talented individuals, with no reports or proj
Jumping Genes A Buyers' Guide
Hillary Sussman | Jun 15, 2003 | 6 min read
Courtesy of Ivan Rayment  CAUGHT IN MID HOP: Structure of the Tn5 transposase/DNA complex No one believed Barbara McClintock in 1951 when she first described DNA that "jumped" from site to site within maize chromosomes, altering the expression of genes near the sites of integration. In due course, these transposable elements, or transposons, were found to be ubiquitous in nature, and 30 years later McClintock won the Nobel Prize. Today transposons have gone from molecular oddity to molec
In A Darwinian World, What Chance For Design?
Steve Bunk | Apr 12, 1998 | 7 min read
Swiss anthropologist Jeremy Narby counts himself among the relatively thin ranks of scientists willing to publicly announce their conviction that nature is "minded," that an intelligence lies behind the development of life. Such a position is heresy to the prevailing scientific view of naturalism, which holds that nature is self-sufficient and the result of undirected processes. These two differing viewpoints usually are framed in the context of a debate between theology and science--creationis

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