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Molecular Cell Biology
Neeraja Sankaran | Sep 17, 1995 | 2 min read
A. Noda, Y. Ning, S.F. Venable, O.M. Pereira-Smith, J.R. Smith, "Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen," Experimental Cell Research, 211:90-8, 1994. (Cited in nearly 150 publications through August 1995) Comments by James R. Smith, Baylor College of Medicine The major finding described in this paper, says James R. Smith, a professor in the division of molecular virology at Baylor College of Medicine and codirector of the Roy M. and Phyllis Gou
Molecular Biology
The Scientist Staff | Jan 6, 1991 | 1 min read
L. Osborn, C. Hession, R. Tizard, C. Vassallo, et al., "Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes," Cell, 59, 1203-11, 22 December 1989. Laurelee Osborn (Biogen Inc., Cambridge, Mass.): "Vascular cell adhesion molecule 1 (VCAM1) is of interest to scientists in several disciplines, particularly those studying cell-cell adhesion mechanism and the mechanisms by which the inflammatory response begins and progre
Molecular Biology
The Scientist Staff | Jan 20, 1991 | 3 min read
C.K. Glass, S.M. Lipkin, O.V. Devary, M.G. Rosenfeld, "Positive and negative regulation of gene transcription by a retinoic acid-thyroid hormone receptor heterodimer," Cell, 59, 697-708, 17 November 1989. Christopher K. Glass (School of Medicine, University of California, San Diego, La Jolla): "Retinoic acid receptors appear to exert profound effects on vertebrate development by binding to target genes and altering the rates at which they are transcribed in response to retinoic acid. Because t
Molecular Biology
The Scientist Staff | Mar 3, 1991 | 1 min read
J.H. Exton, "Signaling through phosphatidylcholine breakdown," The Journal of Biological Chemistry, 265, 1-4, 5 January 1990. John H. Exton (Vanderbilt University School of Medicine, Nashville, Tenn.): "This article was designed to alert readers to the existence of what appears to be a novel cellular signaling system involving the breakdown of phosphatidylcholine to phosphatidic acid. It arose out of the realization that the accumulation of phosphatidic acid in stimulated cells could not be e
Molecular Biology
The Scientist Staff | Jan 19, 1992 | 1 min read
S. Ghosh, A.M. Gifford, L.R. Riviere, P. Tempst, et al., "Cloning of the p50 DNA binding subunit of NF-kB: homology to rel and dorsal," Cell, 62:1019-29, 1990. Sanker Ghosh (Yale University School of Medicine; formerly at Whitehead Institute for Biomedical Research, Cambridge, Mass.): "NF-kB is a transcription factor that is widely used for the inducible expression of a large number of cellular and viral genes. This has resulted in the study of NF-kB by researchers interested in diverse areas
Molecular Biology
The Scientist Staff | Jan 6, 1991 | 1 min read
B. Berkhout, R.H. Silverman, K.-T. Jeang, "Tat trans-activates the human immunodeficiency virus through a nascent RNA target," Cell, 59, 273-82, 20 October 1989. Ben Berkhout (National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Md.): "The unique feature of this study was the use of RNA-refolding mutagenesis. Rearrangement of RNA structures was first described by Charles Yanofsky [Stanford University] to explain the process of transcriptional attenuation ["Transcription atten
Molecular Biology
The Scientist Staff | Dec 6, 1992 | 2 min read
R. Glynne, S. H. Powis, S. Beck, A. Kelly, L-A. Kerr, J. Trowsdale, "A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC," Nature, 353:357-360, 1991. Richard Glynne (Imperial Cancer Research Fund, London, England): "The mechanism by which the body's immune system recognizes and kills virally infected cells but passes over healthy cells has intrigued immunologists for many years. An important breakthrough came when Alain Townsend at the John R
Molecular Biology
The Scientist Staff | Jul 5, 1992 | 1 min read
S.J. Baker, S. Markowitz, E.R. Fearon, J.K.V. Willson, B. Vogelstein, "Suppression of human colorectal carcinoma cell growth by wild- type p53,"Science, 249:912-15, 1990. S.J. Baker, A.C. Preisinger, J.M. Jessup, et al., "p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis," Cancer Research, 50:7717-22, 1990. Bert Vogelstein (Johns Hopkins Oncology Center, Baltimore, Md.): "Cancer represents not one disease but hundreds. Accordingly,
Molecular Biology
The Scientist Staff | Feb 17, 1991 | 3 min read
R.J. Bandziulis, M.S. Swanson, G. Dreyfuss, "RNA-binding proteins as developmental regulators," Genes and Development, 3, 431-7, April 1989. Gideon Dreyfuss (University of Pennsylvania School of Medicine, Philadelphia): "Protein structural comparisons led to the discovery of identifying and unifying features shared by RNA-binding proteins of the nucleus and cytoplasm. Many of these ribonucleoproteins contain an RNA-binding domain (RBD) of approximately 90 amino acids. This amino acid sequence
Molecular Biology
The Scientist Staff | Nov 13, 1994 | 2 min read
C.F. Lesser, C. Guthrie,"Mutations in U6 snRNA that alter splice-site specificity--implications for the active site," Science, 262:1982-88, 1993. Cammie Lesser (Department of Biochemistry and Biophysics, School of Medicine, University of California, San Francisco): "Nuclear pre-mRNA splicing is the process by which the introns- -the noncoding portions of precursor mRNAs--are removed and the coding sequences called exons are ligated

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