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tag gas chromatography mass spectrometry developmental biology

Mass Spectrometry For Advanced Proteomics: A Revolution In Biological Research
The Scientist | Jul 11, 2018 | 1 min read
In this eBook, learn more about proteins through advanced proteomics, via crosslinking, glycomics, ultra high-res spectrometry, and more!
GC-MS Distorts Data?
Jef Akst | Oct 22, 2015 | 2 min read
A study suggests that gas chromatography-mass spectrometry modifies or destroys sample compounds, but some are skeptical.
Mass Spectrometry Applications for Proteomics
Jeffrey Perkel | Aug 19, 2001 | 10+ min read
Click to view the PDF file: Proteomic Mass Spectrometry Equipment Courtesy of CiphergenCiphergen's SELDI process, a MALDI variant that includes a surface-based enrichment step Early in the twentieth century, scientists puzzled over the observation that certain elements that were otherwise physically indistinguishable from each other nevertheless exhibited different radioactive decay characteristics. These elements would ultimately come to be known as isotopes, but at the time this concept was
An Introduction to Metabolomics
An Introduction to Metabolomics
Rebecca Roberts, PhD | Oct 17, 2023 | 5 min read
As the closest reflection of biological phenotype, metabolomics provides critical information about human health and disease.
Lipids in the Spotlight
Carina Storrs | Aug 1, 2012 | 8 min read
A guide to studying lipids using mass spectrometry
Can Mass Spec Really Do That?
Jeffrey M. Perkel | Feb 1, 2010 | 7 min read
By Jeffrey M. Perkel Can Mass Spec Really Do That? Unexpected applications of a technique best known as a proteomics powerhouse. Mass spectrometry (MS) is not just about proteomics, though its star in that field certainly shines bright. As anyone in the drug discovery, food science, petroleum, or chemistry industries can tell you, mass spec is considerably broader than that. “Traditionally it was a technique for looking at relatively small compou
Metabolite profiling
William Wells(wells@biotext.com) | Nov 8, 2000 | 1 min read
In the November Nature Biotechnology Fiehn et al. offer an alternative to the profiling of messenger RNA and protein levels. They use gas chromatography coupled to mass spectrometry (GC/MS) to assay the relative levels of 326 small compounds from a plant leaf extract (Nat Biotech 2000, 18:1157-1161). A simple methanol extraction is followed by derivitization to increase metabolite stability and volatility. Approximately half of the chromatographed compounds can be identified based on retention t
Out-of-the-Box Proteomics Analysis
Paul Thacker | May 12, 2002 | 2 min read
Proteomics may be the hot buzzword in biology, but proteomics researchers still lack the integrated, "off-the-shelf" tools that have come to characterize genomic research. Now, however, San Jose, Calif.-based Thermo Finnigan offers these scientists an all-in-one package with its recently released ProteomeX™ Workstation, a complete proteomics system. The ProteomeX Workstation is a multidimensional liquid chromatography/mass spectrometry (LC/MS) package that combines three successful Thermo
What Kind of Mass Spec User are You?
Jeffrey M. Perkel | Feb 1, 2007 | 5 min read
Whether studying proteins, nucleic acids, or small molecules, there's an ideal configuration for everyone.
Designing a More Accurate Protein Census
Douglas Steinberg | Apr 1, 2001 | 4 min read
Graphic: Leza BerardoneApplied Biosystems will soon begin testing new mass spectrometry machines designed to identify proteins in as many as 1,000 samples per hour. For the machines to work as planned, however, each sample must be prefractionated down to just a handful of proteins, according to Stephen A. Martin, director of the company's proteomics research center in Framingham, Mass. This example suggests how the slower protocols leading to mass spec are as important to the progress of proteom

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