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tag lipoprotein lipase deficiency cell molecular biology genetics genomics ecology developmental biology

The Genetics of Society
Claire Asher and Seirian Sumner | Jan 1, 2015 | 10 min read
Researchers aim to unravel the molecular mechanisms by which a single genotype gives rise to diverse castes in eusocial organisms.
Surpassing the Law of Averages
Jeffrey M. Perkel | Sep 1, 2009 | 7 min read
By Jeffrey M. Perkel Surpassing the Law of Averages How to expose the behaviors of genes, RNA, proteins, and metabolites in single cells. By necessity or convenience, almost everything we know about biochemistry and molecular biology derives from bulk behavior: From gene regulation to Michaelis-Menten kinetics, we understand biology in terms of what the “average” cell in a population does. But, as Jonathan Weissman of the University of Califo
Preimplantation Genetic Diagnosis: The Next Big Thing?
Ricki Lewis | Nov 12, 2000 | 9 min read
Courtesy of David Hill, ART Reproductive Center Inc.Two separated blastomeres subjected to FISH analysis to check the chromosomes. In early October, preimplantation genetic diagnosis (PGD) made headlines when a Colorado couple used assisted reproductive technology (ART) to have a baby named Adam, whose umbilical cord stem cells could cure his six-year-old sister Molly's Fanconi anemia.1 When Adam Nash was a ball of blastomere cells, researchers at the Reproductive Genetics Institute at Illinois
Genetic Parasites and a Whole Lot More
Barry Palevitz | Oct 15, 2000 | 10+ min read
Photo: Ori Fragman, Hebrew University Hordeum spontaneum, the plant studied for BARE-1 retroelements. With genome sequences arriving almost as regularly as the morning paper, the public's attention is focused on genes--new genes to protect crops against pests; rogue genes that make bacteria resistant to antibiotics; faulty genes that, if fixed, could cure diseases such as muscular dystrophy. What many people don't realize is that genes account for only part of an organism's DNA, and in many c
How Orphan Drugs Became a Highly Profitable Industry
Diana Kwon | May 1, 2018 | 10+ min read
Government incentives, advances in technology, and an army of patient advocates have spun a successful market—but abuses of the system and exorbitant prices could cause a backlash.
Notebook
The Scientist Staff | May 11, 1997 | 7 min read
Citing numerous safety concerns, the U.S. Department of Energy (DOE) on May 1 announced it is dismissing the company that manages its beleaguered Brookhaven National Laboratory on Long Island, N.Y. Associated Universities Inc. (AUI), Brookhaven's contractor for 50 years, failed to address the department's "needs and expectations for community relations and environment safety and health stewardship," according to a DOE statement. Such a move is unprecedented for DOE, but Secretary of Energy Fede
Articles Alert
The Scientist Staff | Aug 7, 1988 | 8 min read
The Scientist has asked a group of experts to periodically comment upon recent articles that they have found noteworthy. Their selections, presented here in every issue, we neither endorsements of content nor the result of systematic searching. Rather, they are personal choices of articles they believe the scientific community as a whole may also find interesting. Reprints of any articles cited here may be ordered through The Genuine Article 3501 Market St., Philadelphia, Pa. 19104, or by telep

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