The Scientist Staff | Jun 23, 1991 | 1 min read
D.P. Lane, S. Benchimol, "p53: Oncogene or anti-oncogene?" Genes & Development, 4:1-8, 1990. David Lane (Cancer Research Campaign Laboratories, University of Dundee, Scotland): "Cancer is a multistep process involving genetic damage to several separate genes. In the majority of human cancers, including all the major types (breast, lung, colon), damage to the p53 gene occurs. This seems now to be the most common molecular change in human cancer. The mutations are very subtle, usually changing j