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image: Replication Complications

Replication Complications

By | January 18, 2017

An initiative to replicate key findings in cancer biology yields a preliminary conclusion: it’s difficult.

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Clostridium botulinum produces a transcription factor that can aggregate and self-propagate a prion-like form, leading to genome-wide changes in gene expression in E. coli, according to a study.

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image: How Plant-Soil Feedback Affects Ecological Diversity

How Plant-Soil Feedback Affects Ecological Diversity

By | January 13, 2017

Researchers examine how underground microbes and nutrients affect plant populations.

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A team of scientists was unable to replicate controversial, high-profile findings published in 2011.

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image: Drug Approval Timeline Same as 20 Years Ago

Drug Approval Timeline Same as 20 Years Ago

By | January 9, 2017

A report finds that new medications still take about 12 years to go from patent to patient.

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image: Repurposing Existing Drugs for New Indications

Repurposing Existing Drugs for New Indications

By | January 1, 2017

An entire industry has sprung up around resurrecting failed drugs and recycling existing compounds for novel indications.

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image: Infographic: Repurposing Strategies

Infographic: Repurposing Strategies

By | January 1, 2017

Novel uses for existing and failed drugs may save companies time and money in bringing new therapeutics to market.

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image: More Anti-CRISPR Proteins to Block Cas9

More Anti-CRISPR Proteins to Block Cas9

By | December 29, 2016

The latest CRISPR deactivators to be discovered turn off the Streptococcus pyogenes Cas9 widely used in genome editing.

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image: Life Science Controversies of 2016

Life Science Controversies of 2016

By , , and | December 23, 2016

This year, the developers of CRISPR gene-editing technology argued over patent rights, a researcher fought to unmask anonymous PubPeer commenters, US regulators considered “three-parent” babies, and troubles continued for Theranos.

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image: New CRISPR-Cas Enzymes Discovered

New CRISPR-Cas Enzymes Discovered

By | December 22, 2016

A metagenomics analysis finds Cas9 in archaea for the first time, along with two previously unknown Cas nucleases from bacteria.

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