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tag protein protein interactions immunology

One Protein to Rule Them All
Shelby Bradford, PhD | Feb 28, 2024 | 10+ min read
p53 is possibly the most important protein for maintaining cellular function. Losing it is synonymous with cancer.
Unraveling Protein-Protein Interactions
Leslie Pray | Jan 26, 2003 | 8 min read
Courtesy of Adrian Arakaki THERE'S GOLD IN THEM THERE COMPLEXES: Digging up protein-protein interactions with MULTIPROSPECTOR. Using a computer instead of a pipette, Jeffrey Skolnick contemplates the subtle forces that bring proteins together. His first computational forays helped decipher the quaternary structure of proteins--the interactions between subunits in molecules such as tropomyosin. Now Skolnick, executive director of the Buffalo Center of Excellence in Bioinformatics, Buffalo
Probing Protein Interactions
Laura Defrancesco | Apr 14, 2002 | 8 min read
The challenge of proteomics is personified in the Greek god, Proteus. The keeper of all knowledge, past, present and future, Proteus would not give up any information easily; even while held down, he would struggle and assume different forms before giving anything up. Remarkably, proteomics, and proteins for that matter, were not named after Proteus, but the imagery could not be more fitting. It's still anyone's guess what the final gene count will be in the human genome, let alone the total nu
Protein Purification II: Affinity Tags
Aileen Constans | Feb 17, 2002 | 9 min read
Scientists working with recombinant proteins expressed in Escherichia coli probably use at least one liquid chromatography technique to purify their protein of interest. But liquid chromatography frequently requires a considerable amount of optimization, and usually involves several different chromatographic steps to rid the sample of contaminants.1 The ideal solution would be to create a resin that is completely specific to the target protein, enabling one-step purification. Affinity chromatogr
Abstract graphene structures
Synthetic Organelles Let Researchers Control Cell Behavior
Catherine Offord | Nov 1, 2021 | 3 min read
A technique that reversibly bundles tagged cargo into artificial membraneless compartments gives scientists the ability to switch cell processes on and off.
Tag! Purifying Proteins with Affinity Chromatography
Aileen Constans(aconstans@the-scientist.com) | Feb 27, 2005 | 6 min read
What is now a standard protein laboratory technique began as an act of desperation.
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Bat Immune Systems: The Original Antivirus Programs
Hannah Thomasy, PhD | Mar 15, 2024 | 3 min read
Bats stay healthy while hosting some of the world’s deadliest viruses. Scientists are just beginning to understand how.
A needle drawing up fluid from an unlabeled vial.
Cancer Vaccination as a Promising New Treatment Against Tumors
Shelby Bradford, PhD | Mar 15, 2024 | 10+ min read
Vaccination has beaten back infections for more than a century. Now, it may be the next big step in battling cancer.
A computer-generated graphic showing a cross-section of red-colored bacteria, with the locations of the protein APOL3 labeled in green.
Human Protein Dissolves Bacterial Membranes
Abby Olena, PhD | Jul 15, 2021 | 4 min read
The protein, apolipoprotein L3, destroys invading microbes by acting as a detergent in the cytosol.
A bat flying in a dark cave
Turning on the Bat Signal
Hannah Thomasy, PhD | Mar 15, 2024 | 10+ min read
Scientists around the world investigate how bat immune systems cope with viral attacks and how this information could be used to keep humans safe.

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