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tag sky microbiome genetics genomics microbiology evolution disease medicine

bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Haydeh Payami is wearing a purple dress and an orange and pink scarf and standing in front of a whiteboard.
A Microbial Link to Parkinson’s Disease
Mariella Bodemeier Loayza Careaga, PhD | Dec 4, 2023 | 6 min read
Haydeh Payami helped uncover the genetic basis of Parkinson’s disease. Now, she hopes to find new ways to treat the disease by studying the gut microbiome.
An illustration of green bacteria floating above neutral-colored intestinal villi
The Inside Guide: The Gut Microbiome’s Role in Host Evolution
Catherine Offord | Jul 1, 2021 | 10+ min read
Bacteria that live in the digestive tracts of animals may influence the adaptive trajectories of their hosts.
Bacteria and Humans Have Been Swapping DNA for Millennia
Kelly Robinson and Julie Dunning Hotopp | Oct 1, 2016 | 8 min read
Bacteria inhabit most tissues in the human body, and genes from some of these microbes have made their way to the human genome. Could this genetic transfer contribute to diseases such as cancer?
Illustration showing a puzzle piece of DNA being removed
Large Scientific Collaborations Aim to Complete Human Genome
Brianna Chrisman and Jordan Eizenga | Sep 1, 2022 | 10+ min read
Thirty years out from the start of the Human Genome Project, researchers have finally finished sequencing the full 3 billion bases of a person’s genetic code. But even a complete reference genome has its shortcomings.
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Are Phages Overlooked Mediators of Health and Disease?
Catherine Offord | Feb 1, 2021 | 10+ min read
Bacteria-infecting viruses affect the composition and behavior of microbes in the mammalian gut—and perhaps influence human biology.
Companies Pursue Diagnostics that Mine the Microbiome
Andrea Anderson | May 22, 2017 | 5 min read
Tests so far typically screen for risky patterns that may augment traditional types of clinical data.
mouse in grass microbiome
New Mouse Model Predicts Two Clinical Trial Failures in Humans
Emma Yasinski | Aug 1, 2019 | 4 min read
The lab animals had more natural microbiomes seeded by wild mice, unlike conventional models that are kept in sterile conditions.
Lost Colonies
Anna Azvolinsky | Oct 1, 2015 | 10+ min read
Next-generation sequencing has identified scores of new microorganisms, but getting even abundant bacterial species to grow in the lab has proven challenging.

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