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image: FDA Votes Yes on CAR T-Cell Therapy

FDA Votes Yes on CAR T-Cell Therapy

By | July 13, 2017

A Food and Drug Administration advisory panel unanimously calls for agency approval of the cell therapy for the treatment of resistant leukemia. 

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In two early trials, vaccines tailored to the mutations in individuals’ cancers appeared to protect 12 of 19 patients against relapse. 

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image: CAR T-Cell Trials Boast Promising Results

CAR T-Cell Trials Boast Promising Results

By | June 6, 2017

The results of two small clinical trials show that the immunotherapy is effective for multiple myeloma patients, at least in the near term.

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image: Rare T Cells Fight Cancer

Rare T Cells Fight Cancer

By | May 1, 2017

A new approach to immunotherapy finds that the immune-cell clonotypes that come to the rescue start out at very low frequencies.

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image: Contributors

Contributors

By | April 1, 2017

Meet some of the people featured in the April 2017 issue of The Scientist.

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image: Gel Scaffolds for Delivery of Immunotherapies

Gel Scaffolds for Delivery of Immunotherapies

By | April 1, 2017

Using biocompatible polymers to carry cancer immune therapies directly to the tumor

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image: Making CAR T-Cell Therapy Safer

Making CAR T-Cell Therapy Safer

By | April 1, 2017

Following a spate of patient deaths in clinical trials testing modified T cells for the treatment of cancer, researchers work to reduce the treatment’s toxicity without sacrificing efficacy.

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Measuring PD-L1 levels was a great start. Now we need to quantify more protein biomarkers, assess the tumor mutational landscape, and examine immune cell signatures, too.

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image: Neoantigens Enable Personalized Cancer Immunotherapy

Neoantigens Enable Personalized Cancer Immunotherapy

By | April 1, 2017

Tumors’ mutations can encode the seeds of their own destruction, in the form of immunogenic peptides recognized by T cells.

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image: Infographic: Antibody Cancer Therapy

Infographic: Antibody Cancer Therapy

By | April 1, 2017

An experimental technique removes T cells that aid in vitro tumor growth.

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