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tag cpg dna evolution disease medicine

Building Nanoscale Structures with DNA
Arun Richard Chandrasekaran | Jul 16, 2017 | 10+ min read
The versatility of geometric shapes made from the nucleic acid are proving useful in a wide variety of fields from molecular computation to biology to medicine.
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Illustration showing a puzzle piece of DNA being removed
Large Scientific Collaborations Aim to Complete Human Genome
Brianna Chrisman and Jordan Eizenga | Sep 1, 2022 | 10+ min read
Thirty years out from the start of the Human Genome Project, researchers have finally finished sequencing the full 3 billion bases of a person’s genetic code. But even a complete reference genome has its shortcomings.
multicolor DNA sequencing gel
Genetic Mutations Can Be Benign or Cancerous—a New Method to Differentiate Between Them Could Lead to Better Treatments
Ryan Layer, The Conversation | May 27, 2022 | 5 min read
Tumors contain thousands of genetic changes, but only a few are actually cancer-causing. A quicker way to identify these driver mutations could lead to more targeted cancer treatments.
Methylation: Gene Expression at the Right Place and Right Time
Nadia Halim | Dec 5, 1999 | 7 min read
Courtesy of Richard Roberts, New England BiolabsModel methylation reaction: Cytosine nucleotide (red) is flipped out of the DNA double helix by a methyltransferase (white), so it can be methylated. The end product after the methyl group has been transferred to the DNA is pictured in green. A tenuous link between DNA methylation and development has existed for several years. Now findings substantiate the connection. Researchers have found the first human diseases caused by defects in the DNA meth
Top 10 Innovations 2021
2021 Top 10 Innovations
The Scientist | Dec 1, 2021 | 10+ min read
The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.
Notebook
Steve Bunk | Nov 7, 1999 | 7 min read
Content Jumping DNA Semen pharming Screening for heart risk Real-time signaling PubSCIENCE starts, PubMedCentral grows When time stands still Shutting down the pump Brain gain JUMPING DNA Mutations aren't transmitted only by inheritance--they can cross species, too, according to recent findings by John F. McDonald, head of the genetics department at the University of Georgia (I.K. Jordan et al., "Evidence for the recent horizontal transfer of long terminal repeat retrotransposon," Proceedings of
Research Notes
Nadia Halim | Feb 20, 2000 | 6 min read
Methylation as a Cancer Switch Courtesy of Richard Roberts, New England BiolabsReaction model: Methyltransferase (white) is methylating cyclic carbon 5 of a cytosine nucleotide. The tenuous link between cancer and epigenetic changes, changes in gene expression without DNA mutations, has been strengthened by Joe Costello, assistant professor at the University of California, San Francisco, and colleagues (J.F. Costello et al., "Aberrant CpG-island methylation has non-random and tumour-type-specifi
Updated July 9
Track COVID-19 Vaccines Advancing Through Clinical Trials
The Scientist | Apr 7, 2020 | 10+ min read
Find the latest updates in this one-stop resource, including efficacy data and side effects of approved shots, as well as progress on new candidates entering human studies.
Chromosome 21 Reveals Sparse Gene Content
Ricki Lewis | Jun 11, 2000 | 8 min read
The unveiling of the DNA sequences of human chromosomes represents a new chapter in the unfolding story of genomics, but one with roots in the half-century-old field of cytogenetics. Chromosome-level looks can reveal the specific genes behind certain traits and disorders while providing information on genome organization. The diminutive chromosome 21--the smallest of the human contingent, despite its number as next to last--is the fourth to be described. Its debut in mid-May attracted attentio

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