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tag cytochrome p450 culture

The Importance of ADMET in Early Drug Discovery and Development
Sartorius | Jun 3, 2020 | 4 min read
A conversation with Mandy Xu of Pharmaron about characterizing promising pharmacological compounds
Lonza Announces New Offering of Silensomesā„¢ HLM for Drug Metabolism Studies
Lonza | Nov 9, 2017 | 2 min read
Today Lonza Walkersville announced its new offering of Silensomes™ Human Liver Microsomes (HLM) products – pooled human liver microsomes for in vitro cytochrome P450 (CYP) phenotyping. CYP phenotyping is a regulatory requirement for new drug candidates to understand their metabolism and to predict drug-drug interactions.
InSphero Launches Multi-donor Human Liver Microtissues.
InSphero | Mar 15, 2016 | 2 min read
3D human liver microtissues comprised of pooled hepatocytes from multiple donors offers...
Lonza to Present Latest Research into More Physiologically Relevant ADME-Tox Models at the Society of Toxicology Meeting
Lonza | Feb 1, 2018 | 5 min read
During the Society of Toxicology Meeting from 11-15 March 2018 at the Henry B. González Convention Center in San Antonio, TX (USA), Lonza will present two posters highlighting its latest research into developing more physiologically relevant in vitro cell-culture models for ADME-Tox testing. 
New Technologies Shed Light on Caveolae
Ben Nichols | Jun 1, 2018 | 10+ min read
The functions of the cellular invaginations identified more than half a century ago are now beginning to be understood in detail.
Top 10 Innovations 2016
The Scientist | Dec 1, 2016 | 10+ min read
This year’s list of winners celebrates both large leaps and small (but important) steps in life science technology.
New source of liver cells
Tudor Toma(t.toma@ic.ac.uk) | May 20, 2002 | 1 min read
Until recently, it was believed that hepatocytes could only be derived from cells of endodermal origin and their progenitors. But, in 15 May Journal of Clinical Investigation, Robert Schwartz and colleagues from University of Minnesota, Minneapolis, USA, show that adult bone marrow stem cells can differentiate in vitro to cells exhibiting hepatocyte phenotype and function (J Clin Invest 2002, 109:1291-1302).Schwartz et al. cultured bone marrow-derived human, murine and rat multipotent adult prog
RNA Interference Between Kingdoms
Kerry Grens | Feb 1, 2017 | 10+ min read
Plants and fungi can use conserved RNA interference machinery to regulate each other’s gene expression—and scientists think they can make use of this phenomenon to create a new generation of pesticides.
The Inequality of Drug Metabolism
Karen Young Kreeger | Mar 17, 2002 | 6 min read
Editor's Note: This is the fifth article in a series on sex-based differences in the biology of males and females. The final article in the series will cover sex-based differences in life expectancy. Lisa Damiani More than 30 years ago, researchers noted for the first time the pharmacokinetic differences between men and women. They found that women pass antipyrine, a drug used to study liver metabolism, more quickly than men; this occurred around ovulation and during the luteal phase of their m
Flow Cytometry for the Masses
Richard P. Grant | Dec 1, 2011 | 2 min read
Tagging antibodies with rare earth metals instead of fluorescent molecules turns a veteran technique into a high-throughput powerhouse.

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