From smart receptors to novel biologics, scientists plan to overcome the challenges of treating solid tumors.

A risk-benefit analysis of gene editing tools in stem cells revealed that base and prime editing carry vulnerabilities similar to those of CRISPR-Cas9, but at a reduced rate. 

A trio of papers shows that specialized antibodies can direct T cells to destroy cells that display portions of mutant cancer-related proteins, as well as T cells that have become cancerous themselves.

Genetic changes that may initiate childhood leukemia could originate while the baby is still in utero.

Mutations in the TP53 gene appear to influence the prognosis and likelihood of future cancers in pediatric leukemia patients.

Bioengineered bacteria sneak past solid tumor defenses to guide CAR T cells’ attacks.

With much of his early career dictated by US Navy interests, Carl June drew inspiration from malaria, bone marrow transplantation, and HIV in his roundabout path to a breakthrough in cancer immunotherapy.

Early exposure to common microbes could stop leukemia from manifesting in children.

Through his studies on cancer-causing viruses, the University of California, Los Angeles, professor has helped develop lifesaving treatments.

A TELLING EXPRESSION:© 2002 ElsevierExpression patterns for 7 and 20 genes that were selected as discriminators of relapse versus continuous complete remission (CCR) for two types of acute lymphoblastic leukemia, T-ALL and hyperdiploid >50 ALL. (from E-.J. Yeoh et al., Cancer Cell 1:133–43, 2002.)Countless things can go wrong in the complicated cell division process. Checkpoints fail, genomic instability increases, and when anarchy reigns, cancers spread. In trying to assess what is d