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tag cloning culture genetics genomics ecology

bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Beyond the Blueprint
Jennifer A. Schweitzer, Mark A. Genung, and Joseph K. Bailey | Sep 1, 2014 | 10+ min read
In addition to serving as a set of instructions to build an individual, the genome can influence neighboring organisms and, potentially, entire ecosystems.
Advances in the functional characterization of newly discovered microproteins hint at their diverse roles  in health and disease
The Dark Matter of the Human Proteome
Annie Rathore | Apr 1, 2019 | 10 min read
Advances in the functional characterization of newly discovered microproteins hint at diverse roles in health and disease.
A fruit bat in the hands of a researcher
How an Early Warning Radar Could Prevent Future Pandemics
Amos Zeeberg, Undark | Feb 27, 2023 | 8 min read
Metagenomic sequencing can help detect unknown pathogens, but its widespread use faces challenges.
The Ecology of Tumors
Paraic A. Kenny, Celeste M. Nelson, and Mina J. Bissell | Apr 1, 2006 | 10+ min read
FEATUREThe Ecology of Tumors   Courtesy of Nasa Ames Research CenterBy perturbing the microenvironment, wounds and infection may be key to tumor development.BY PARAIC A. KENNY, CELESTE M. NELSON, AND MINA J. BISSELLNo tumor is an island. Chemical and physical forces exerted by the diverse cellular populations that surround a tumor - its so-called microenvironment - shape development and progression. Manipulating these 'ecologi
Don't Clone Alone
Laura Defrancesco | Sep 14, 1997 | 10 min read
Date: September 15, 1997 cDNA Library Kit Table and Species Chart Pre-made cDNA libraries and kits abound in the market to help you probe the secrets of gene regulation while minimizing the drudgery of cDNA library construction. The ability to analyze a cell's genetic read-out-to determine which of the 100,000 possible genes are actually being expressed in a cell or tissue-is to know what makes a cell what it is. This is a central issue in molecular biology. For decades, cDNA libraries-colle
Genetic Parasites and a Whole Lot More
Barry Palevitz | Oct 15, 2000 | 10+ min read
Photo: Ori Fragman, Hebrew University Hordeum spontaneum, the plant studied for BARE-1 retroelements. With genome sequences arriving almost as regularly as the morning paper, the public's attention is focused on genes--new genes to protect crops against pests; rogue genes that make bacteria resistant to antibiotics; faulty genes that, if fixed, could cure diseases such as muscular dystrophy. What many people don't realize is that genes account for only part of an organism's DNA, and in many c
heath hen Tympanuchus cupido de-extinction grouse pgc germline transmission cultured germ cell transmission
The Booming Call of De-extinction
W. S. Roberts | Oct 19, 2020 | 6 min read
Scientists seek to combine genome editing with a technique used in chicken breeding to try to bring back lost birds.
Getting to Megabase
Jorge Cortese | Dec 5, 1999 | 7 min read
Large Fragment Cloning Products and Services Gone are the days when all you had to do to get out of grad school was identify and clone a new gene. Besides, with the information rapidly gathered through the Human Genome Project, there will soon no longer be a "new gene." Enormous projects such as sequencing entire genomes have created a need to play with bigger pieces of the puzzle, and a new universe of technologies adapted to large DNA fragments has appeared. Assignment of a new gene to a par
Epigenetics: Genome, Meet Your Environment
Leslie Pray | Jul 4, 2004 | 10+ min read
©Mehau Kulyk/Photo Researchers, IncToward the end of World War II, a German-imposed food embargo in western Holland – a densely populated area already suffering from scarce food supplies, ruined agricultural lands, and the onset of an unusually harsh winter – led to the death by starvation of some 30,000 people. Detailed birth records collected during that so-called Dutch Hunger Winter have provided scientists with useful data for analyzing the long-term health effects of prenat

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