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» epigenome

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image: Opinion: Engineering the Epigenome

Opinion: Engineering the Epigenome

By , and | August 26, 2015

The use of targetable chromatin modifiers has ushered in a new era of functional epigenomics.

1 Comment

image: New Epigenetic Mark Found on Metazoan DNA

New Epigenetic Mark Found on Metazoan DNA

By | April 30, 2015

Three studies identify roles for N6-methyladenosine in algae, worms, and flies.

3 Comments

image: CRISPR–Enabled Epigenome Editing

CRISPR–Enabled Epigenome Editing

By | April 6, 2015

Researchers apply the genome-editing technology to alter histones at distant gene enhancers, controlling gene expression.

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image: Exploring the Epigenome

Exploring the Epigenome

By | February 18, 2015

A National Institutes of Health-funded consortium publishes 111 reference maps of DNA and histone marks.

2 Comments

image: Methylation Tied to Alzheimer’s

Methylation Tied to Alzheimer’s

By | August 20, 2014

People with the neurodegenerative disease are more likely to have certain epigenetic patterns than those without.

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image: Epigenetic Changes Can Cause Cancer

Epigenetic Changes Can Cause Cancer

By | July 25, 2014

A transgene designed to attract methylation to the promoter of a tumor-suppressor gene leads to tumorigenesis in a mouse model. 

4 Comments

image: Gestational Malnutrition Affects Offspring’s Sperm

Gestational Malnutrition Affects Offspring’s Sperm

By | July 10, 2014

Mice undernourished during pregnancy can transmit the effects of such nutritional stress to their sons’ germ cells, epigenetically.  

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image: Brain Methylation Map Published

Brain Methylation Map Published

By | July 4, 2013

The epigenetic modification of brain cells undergoes great shifts over the course of mouse and human development.

2 Comments

image: An Epi Phenomenon

An Epi Phenomenon

By | December 1, 2012

While exploring the genetics of a rare type of tumor, Stephen Baylin discovered an epigenetic modification that occurs in most every cancer—a finding he’s helping bring to the clinic.

5 Comments

image: Blood Spots Are Epigenetic Time Capsules

Blood Spots Are Epigenetic Time Capsules

By | August 22, 2012

Researchers show that blood spotted onto Guthrie cards, usually at birth, can be a high quality source of methylated DNA for long-term epigenetic studies.

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