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tag bias developmental biology

Top 7 in developmental biology
Bob Grant | Oct 4, 2010 | 3 min read
Check out the hottest papers in developmental biology and related fields, as ranked by F1000
Surpassing the Law of Averages
Jeffrey M. Perkel | Sep 1, 2009 | 7 min read
By Jeffrey M. Perkel Surpassing the Law of Averages How to expose the behaviors of genes, RNA, proteins, and metabolites in single cells. By necessity or convenience, almost everything we know about biochemistry and molecular biology derives from bulk behavior: From gene regulation to Michaelis-Menten kinetics, we understand biology in terms of what the “average” cell in a population does. But, as Jonathan Weissman of the University of Califo
How to Track Cell Lineages As They Develop
Kelly Rae Chi | Dec 1, 2016 | 7 min read
Sequencing and gene-editing advances make tracing a cells journey throughout development easier than ever.
The Genetics of Society
Claire Asher and Seirian Sumner | Jan 1, 2015 | 10 min read
Researchers aim to unravel the molecular mechanisms by which a single genotype gives rise to diverse castes in eusocial organisms.
Unmasking Secret Identities
Kate Yandell | Feb 1, 2014 | 9 min read
A tour of techniques for measuring DNA hydroxymethylation
Assessing Differential Gene Expression
Barbara Cunningham | Nov 25, 2001 | 9 min read
As the complete human genome sequence emerges, research shifts from questions of genomics to those of proteomics--determining the function of individual gene products and mapping global gene expression patterns. Gene expression patterns change continually during the course of tissue development and differentiation. The expression of different gene products at any given time within a particular cell defines the cell's characteristics and helps determine how it will react to external stimuli. Alte
Research Notes
Nadia Halim | Sep 3, 2000 | 5 min read
Stopping Ebola in Its Tracks Richard Preston brought the threat of emerging infectious diseases to the consciousness of his readers in The Hot Zone. The book graphically describes how the Ebola virus causes massive internal bleeding, which kills up to 90 percent of the people it infects. Now National Institutes of Health scientists are making promising advances to stop disease spread. Researchers have identified a viral protein that destroys endothelial cells, the cells that line the blood vess
Preimplantation Genetic Diagnosis: The Next Big Thing?
Ricki Lewis | Nov 12, 2000 | 9 min read
Courtesy of David Hill, ART Reproductive Center Inc.Two separated blastomeres subjected to FISH analysis to check the chromosomes. In early October, preimplantation genetic diagnosis (PGD) made headlines when a Colorado couple used assisted reproductive technology (ART) to have a baby named Adam, whose umbilical cord stem cells could cure his six-year-old sister Molly's Fanconi anemia.1 When Adam Nash was a ball of blastomere cells, researchers at the Reproductive Genetics Institute at Illinois
Genetic Parasites and a Whole Lot More
Barry Palevitz | Oct 15, 2000 | 10+ min read
Photo: Ori Fragman, Hebrew University Hordeum spontaneum, the plant studied for BARE-1 retroelements. With genome sequences arriving almost as regularly as the morning paper, the public's attention is focused on genes--new genes to protect crops against pests; rogue genes that make bacteria resistant to antibiotics; faulty genes that, if fixed, could cure diseases such as muscular dystrophy. What many people don't realize is that genes account for only part of an organism's DNA, and in many c

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