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Mouse running on wheel
An Exercise-induced Liver Enzyme Boosts Metabolism
Exercise drives the liver to produce the CES2 enzyme, which circulates in blood and delivers some of the benefits of exercise in mice. 
An Exercise-induced Liver Enzyme Boosts Metabolism
An Exercise-induced Liver Enzyme Boosts Metabolism

Exercise drives the liver to produce the CES2 enzyme, which circulates in blood and delivers some of the benefits of exercise in mice. 

Exercise drives the liver to produce the CES2 enzyme, which circulates in blood and delivers some of the benefits of exercise in mice. 

liver

The face of a young woman and the face of an old man surrounded by mechanical clocks.
Daily Gene Expression Rhythms Vary with Sex and Age: Study
Alejandra Manjarrez, PhD | Feb 2, 2023 | 3 min read
By studying tissues from deceased people, a team found that women have more rhythmical gene expression and that this molecular rhythmicity decreases with age.
A nine-banded armadillo walking on dry grass.
Leprosy Bacterium Rejuvenates Armadillos’ Livers
Alejandra Manjarrez, PhD | Nov 15, 2022 | 4 min read
Mycobacterium leprae appeared to reprogram the animals’ livers to a state partially resembling early development, resulting in healthy organ growth.
Beyond Gravity: Immune-Mediated Liver Damage in Spaceflight
Beyond Gravity: Immune-Mediated Liver Damage in Spaceflight
The Scientist | 1 min read
In this webinar, Noah Allen will explore how spaceflight changes the way organs and systems function, focusing on immune-mediated liver damage.
illustration of liver with veins in blue and arteries in red.
Ethanol-Making Microbe Tied to Nonalcoholic Fatty Liver Disease
Natalia Mesa, PhD | Oct 19, 2022 | 4 min read
A study adds to evidence linking gut bacteria to liver conditions in people who don’t drink excessive amounts of alcohol. 
Histology of mouse lungs using purple and green staining on a white background. Left: a healthy lung. Right: a fibrotic lung.<br><br>
Immunotherapy Treats Fibrosis in Mice
Alejandra Manjarrez, PhD | Sep 15, 2022 | 4 min read
Researchers report that vaccination against proteins found on profibrotic cells reduced liver and lung fibrosis in laboratory rodents.
fuorescence microscopy of kidney tissue
Artificial Blood Breathes New Life Into Dead Pigs’ Cells
Andy Carstens | Aug 3, 2022 | 2 min read
A study’s authors say their oxygenating cocktail may lead to technologies that preserve organs in deceased people for longer periods for transplantation.
Ribbon diagram of the protein coat of an adeno-associated virus
Preprints Propose Constellation of Causes for Kids’ Liver Disease
Christie Wilcox, PhD | Jul 25, 2022 | 2 min read
Two independent groups suggest the suite of recent unexplained hepatitis cases may stem from coinfection with an adeno-associated virus and a helper adeno- or herpesvirus, a duo which may be especially virulent in children with a particular genetic variant.
Liver glowing red underneath human torso
Mysterious Hepatitis Cases Reported in Young Children
Natalia Mesa, PhD | Apr 18, 2022 | 3 min read
Officials have ruled out known hepatitis viruses as the cause of a rash of illnesses in Europe and the US.
mice on wheel and ground
Exercise-Associated Protein Boosts Brain Function in Mice
Chloe Tenn | Dec 9, 2021 | 5 min read
A study that transfused plasma from active to inactive mice suggests the protein clusterin enhances cognition.
Conceptual illustration of cells releasing cytokines in various shades of blue
Spleen-to-Liver Signals Control Systemic Inflammation
Ruth Williams | Apr 29, 2021 | 3 min read
In rats, the spleen directs a cytokine surge that drives system-wide inflammation, but it is not, as once believed, the main producer of the chemical messenger.
Organoids Repair Bile Ducts
Abby Olena, PhD | Feb 18, 2021 | 4 min read
Researchers determined that when introduced into damaged mouse or donated human livers, these lab-grown tissues could integrate into bile ducts and function normally.
Stress-Induced Chromosome Changes Protect Flies’ Aging Brains
Lisa Winter | Dec 1, 2020 | 2 min read
Brain cells in older Drosophila tend to have more than two complete sets of chromosomes, and that polyploidy most likely has a protective function, a study shows.
Image of the Day: Red-Feathered Finches
Emily Makowski | Sep 30, 2019 | 1 min read
Scientists uncover a potential reason why redder house finches have better health.
Gut Microbe Linked to Nonalcoholic Fatty Liver Disease
Abby Olena, PhD | Sep 19, 2019 | 3 min read
Researchers find strains of the bacterium Klebsiella pneumoniae that produce high levels of alcohol in 60 percent of patients with the condition.
exosome cancer liver hepatocellular carcinoma RNA cirrhosis
Exosomes from Blood Carry RNA Signatures of Liver Cancer
Emma Yasinski | Apr 2, 2019 | 2 min read
A small study finds that the tiny extracellular vesicles from patients with hepatocellular carcinoma have RNA content distinct from patients with cirrhosis only.
Just the Sight of Food Gets the Liver Ready for Action
Abby Olena, PhD | Nov 15, 2018 | 3 min read
In mice, seeing and smelling food causes immediate cellular changes that ready the liver to convert incoming amino acids to proteins.
CRISPR Editing Heads Off Disease in Mouse Livers
Shawna Williams | Oct 9, 2018 | 2 min read
Separate proof-of-concept studies report success against two inherited diseases.
Limited Meal Times Prevent Obesity in Mice Prone to Gaining Weight
Abby Olena, PhD | Aug 30, 2018 | 3 min read
Even in mice with a busted circadian clock and an unhealthy diet, carefully timed feeding overcomes the rodents’ predispositions for metabolic diseases.
Reprogrammed Cells Treat Diabetes in Mice
Abby Olena, PhD | May 2, 2018 | 3 min read
Researchers used a trio of transcription factors to transform pancreatic duct cells in vivo into β-like cells that secrete insulin and improve diabetes symptoms.
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