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bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Guts and Glory
Anna Azvolinsky | Apr 1, 2016 | 9 min read
An open mind and collaborative spirit have taken Hans Clevers on a journey from medicine to developmental biology, gastroenterology, cancer, and stem cells.
Gene Splicing Pioneer Dale Kaiser Dies
Ashley Yeager | Jun 29, 2020 | 5 min read
Working with a virus that infects bacteria, the Stanford University biochemist and developmental biologist helped to develop a way to stitch DNA together, a discovery that gave rise to genetic engineering.
The Biological Basis for Atherosclerosis
Jennifer Fisher Wilson | Oct 29, 2000 | 5 min read
For this article, Jennifer Fisher Wilson interviewed Ronald M. Evans, Howard Hughes Medical Institute investigator and director of the Gene Expression Laboratory at the Salk Institute for Biological Studies in La Jolla, Calif., and Peter Tontonoz, now assistant HHMI investigator and assistant professor in the pathology and laboratory medicine department at University of California, Los Angeles. Data from the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more o
New Molecular Tools Enable Researchers To Correlate Viruses, Diseases
Karen Young Kreeger | Feb 4, 1996 | 7 min read
Viruses, Diseases Author: Karen Young Kreeger Sidebar: Professional Resources for Viral Disease Researchers In the mid- to late 1980s, numerous correlations were discovered between viruses and various types of cancers. For example, Epstein-Barr virus was associated with nasopharyngeal carcinoma and B-cell lymphoma, hepatitis B virus with liver cancer, and human papillomavirus with cervical cancer. Now, a decade later, basic and clinical scientists are finding out that viruses may also play a r
Making a Play at Regrowing Hearts
Kenneth Chien | Aug 1, 2006 | 10 min read
FEATURECardiac Stem Cells Results from the first round of controlled human stem cell trials for heart disease are in. What have we learned?BY KENNETH CHIENA bleedng heart, Dicentra formosa © ROBERT ESSEL NYC/CORBISFor patients with chronic degenerative diseases such as heart failure, regenerative medicine holds great promise. It is this compelling need that has created a sense of urgency, leading t
Monoclonal Antibodies Find Utility In Cell Biology
Ricki Lewis | Dec 11, 1994 | 10+ min read
But, just as antibodies are finding increasing utility in cell biology, a new Food and Drug Administration classification for those products with clinical utility may affect researchers' access to the important technology (see accompanying story). Monoclonal History MAbs were born in 1975, when Georges Kohler and Cesar Milstein at the Medical Research Council Laboratories in Cambridge, England, fused two types of cells to form a hy
Monoclonal Antibodies Find Utility In Cell Biology
Ricki Lewis | Dec 11, 1994 | 10+ min read
But, just as antibodies are finding increasing utility in cell biology, a new Food and Drug Administration classification for those products with clinical utility may affect researchers' access to the important technology (see accompanying story). Monoclonal History MAbs were born in 1975, when Georges Kohler and Cesar Milstein at the Medical Research Council Laboratories in Cambridge, England, fused two types of cells to form a hy
Eat Yourself to Live: Autophagy’s Role in Health and Disease
Vikramjit Lahiri and Daniel J. Klionsky | Mar 1, 2018 | 10+ min read
New details of the molecular process by which our cells consume themselves point to therapeutic potential.
The dark matter of disease
Hannah Waters | Apr 24, 2011 | 5 min read
Scientists are beginning to unravel how non-coding DNA works across long distances of the genome to influence disease

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