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tag phosphatidylinositol pi 3 kinase cell molecular biology culture

From kinase to cancer
Lewis Cantley | Dec 1, 2007 | 10+ min read
From kinase to cancer The story of discovering PI3 kinase, and what it means for a fundamental pathway in cancer. By Lewis Cantley In 1987 I attended a meeting at Cold Spring Harbor on phosphatidylinositol signaling that turned out to be pivotal for me. A few years earlier I'd helped show that a phosphatidylinositol (PI) kinase activity copurified with various oncoprotein tyrosine kinases, and that this association was critical for the ability of these oncoproteins to tran
Cell Biology
The Scientist Staff | Aug 21, 1994 | 2 min read
J.M. Backer, M.G. Myers, Jr., S.E. Shoelson, D.J. Chin, X.J. Sun, M. Miralpeix, P. Hu, B. Margolis, E.Y. Skolnik, J. Schlessinger, M.F. White, "Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation," EMBO Journal, 11:3469-79, 1992. Morris F. White (Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston): "Nailing down the pathways involved in insulin signaling
Cell Biology
The Scientist Staff | Aug 21, 1994 | 2 min read
J.M. Backer, M.G. Myers, Jr., S.E. Shoelson, D.J. Chin, X.J. Sun, M. Miralpeix, P. Hu, B. Margolis, E.Y. Skolnik, J. Schlessinger, M.F. White, "Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation," EMBO Journal, 11:3469-79, 1992. Morris F. White (Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston): "Nailing down the pathways involved in insulin signaling
Tagged for Cleansing
Michele Pagano | Jun 1, 2009 | 10+ min read
Tagged for Cleansing Not just the cell's trash and recycling center, the ubiquitin system controls complex cellular pathways with elegant simplicity and precision. By Michele Pagano have always gravitated toward order. I may even take it a bit too far according to friends who liken my office to a museum. However, I like to think it not a compulsion, but a Feng Shui approach to life. With this need for order, I may have been better suited to
A rendering of a human brain in blue on a dark background with blue and white lines surrounding the brain to represent the construction of new connections in the brain.
Defying Dogma: Decentralized Translation in Neurons
Danielle Gerhard, PhD | Sep 8, 2023 | 10+ min read
To understand how memories are formed and maintained, neuroscientists travel far beyond the cell body in search of answers.
a false color transmission electron microscope image of a neuronal cell body, with lysosomes colored dark green
Scientists Uncover Major Pathway Cells Use to Mend Leaky Lysosomes
Holly Barker, PhD | Oct 6, 2022 | 3 min read
Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say.
Top 7 papers in cell biology
Jef Akst | Dec 5, 2010 | 3 min read
Just in time for ASCB -- see the cell biology articles most highly ranked by F1000
Genetics
The Scientist Staff | Dec 6, 1998 | 3 min read
H. Kiyokawa, R.D. Kineman, K.O. Manova-Todorova, V.C. Soares, E.S. Hoffman, M. Ono, D. Khanam, A.C. Hayday, L.A. Frohman, and A. Koff. "Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27Kip1," Cell, 85:721-32, 1996. (Cited in more than 155 papers since publication) Comments by Andrew Koff, associate member of the molecular biology program, Memorial Sloan-Kettering Cancer Center, New York Cyclin-dependent kinase (CDK) inhibitors act as a traffic cop of cell
A mutated cell with a spiky membrane
Mutations in Autism-Linked Gene Cause Membrane Mischief
Holly Barker, PhD, Spectrum | Jan 26, 2023 | 4 min read
Inactivating TAOK1 prompts tentacle-like protrusions to form all over a neuron’s surface, revealing the gene’s role in molding the membrane.
Artists' renditions of cancer cells and tRNA molecules superimposed over one another.
Long noncoding RNAs and Microproteins Can Spark Cancer—or Sometimes Squelch It
Rachael Moeller Gorman | Mar 1, 2023 | 10+ min read
Noncoding RNAs and microproteins, once considered genomic noise, are turning out to be critical to the progression of some types of cancer.

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