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tag zinc finger nuclease developmental biology disease medicine

Illustration of DNA
Can “Gene Writing” Deliver What Gene Editing Can’t?
Dan Robitzski | Dec 12, 2022 | 10+ min read
A biotech startup called Tessera Therapeutics has made a splash with its claims about the trademarked technology. Is the excitement justified?
Researchers Engineer Epigenome Editors to Study How Gene Expression Affects Disease
Ashley Yeager | Jan 1, 2019 | 7 min read
Using CRISPR and other tools, scientists are modifying DNA methylation, histone marks, and other modifiers of gene expression to understand how they affect health and disease.
Stuart Orkin
In Our Blood: A Profile of Stuart Orkin
Anna Azvolinsky | Jul 15, 2019 | 9 min read
By unraveling the molecular underpinnings of inherited blood disorders, the Boston Children’s Hospital researcher has provided the basis for therapies now being tested for beta-thalassemia and sickle cell disease.
Using CRISPR to Edit Genes in Induced Pluripotent Stem Cells
Kelly Rae Chi | Sep 1, 2016 | 8 min read
Tips on how to surmount the challenges of working with CRISPR to manipulate genes in human stems cells to study their function in specific diseases or to correct genetic defects in patient cells.
Gene Editing: From Roots to Riches
Amanda B. Keener | Oct 1, 2016 | 5 min read
Advances in genetic manipulation have simplified the once daunting task of rewriting a gene.
labtools march 2019 the scientist dna
The Challenge of Using CRISPR to Knock In Genes
Anna Nowogrodzki | Mar 1, 2019 | 7 min read
Researchers are developing an array of techniques for accurately and efficiently inserting genes into DNA.
The Biggest Science News of 2018
Kerry Grens | Dec 27, 2018 | 7 min read
From disastrous scientific setbacks to the upending of scientific dogma and the end of a 40-year search for a protein
2019 Top 10 Innovations
The Scientist | Dec 1, 2019 | 10+ min read
From a mass photometer to improved breath biopsy probes, these new products are poised for scientific success.
Loaded Words
John D. Loike | Dec 1, 2014 | 4 min read
As new technologies emerge, we must choose our words for them with care: names can negatively bias the inevitable debates over the ethics of scientific advances.
Commander of an Immune Flotilla
Jef Akst | Apr 1, 2014 | 9 min read
With much of his early career dictated by US Navy interests, Carl June drew inspiration from malaria, bone marrow transplantation, and HIV in his roundabout path to a breakthrough in cancer immunotherapy.

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