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image: Smoking-Linked Cancer Mutations Mapped

Smoking-Linked Cancer Mutations Mapped

By | November 3, 2016

Scientists produce a detailed genomic map of mutations and epigenetic changes associated with smoking tobacco across 17 tumor types. 

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image: Sequencing Reveals Genomic Diversity of the Human Brain

Sequencing Reveals Genomic Diversity of the Human Brain

By | September 16, 2016

Researchers examine the role of long interspersed element-1 retrotransposition in neuronal mosaicism.

4 Comments

image: Monitoring Mitochondrial Mutations

Monitoring Mitochondrial Mutations

By | April 18, 2016

Induced pluripotent stem cells—particularly those generated from older patients—should be screened for defects in mitochondrial DNA, a study shows.

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image: Low Mutation Rate in iPSCs

Low Mutation Rate in iPSCs

By | April 11, 2016

The mutation rate in induced pluripotent stem cells is 10 times lower than in somatic cells, scientists show.

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image: Mosaic Mutations May Not Be Rare

Mosaic Mutations May Not Be Rare

By | June 5, 2015

Somatic mosaicism may be responsible for a larger proportion of genomic variability within humans than previously thought.

2 Comments

image: Personalized Cancer Vaccines

Personalized Cancer Vaccines

By | April 2, 2015

A dendritic cell vaccine targeting melanoma patients’ tumor-specific mutations can activate a broad range of cancer-fighting T cells. 

2 Comments

image: Stem Cell Divisions Help Explain Cancer Risk

Stem Cell Divisions Help Explain Cancer Risk

By | January 1, 2015

An analysis of 31 tissues finds that random mutations acquired during stem cell divisions correlate with lifetime cancer risk—more so than heritable mutations and environmental factors combined.  

7 Comments

image: Mosaic Mutations

Mosaic Mutations

By | July 31, 2014

Some genetic abnormalities that appear to have sprung up independently in children are in fact present in a portion of their parents’ cells.

3 Comments

image: Mutation Patterns Underlie Cancers

Mutation Patterns Underlie Cancers

By | August 15, 2013

More than 20 genome-wide mutational “signatures” account for the vast majority of 30 common cancers.

2 Comments

image: New Type of DNA Discovered?

New Type of DNA Discovered?

By | March 8, 2012

Small circles of extrachromosomal DNA appear to be widespread in mammals, and may be byproducts of small deletions in the nuclear DNA of somatic cells.

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