The Scientist

» somatic mutations

Most Recent

image: Abundant Sequence Errors in Public Databases

Abundant Sequence Errors in Public Databases

By | February 16, 2017

A new algorithm reveals hoards of preparation-induced DNA mutations in publicly available human sequences.

1 Comment

image: Smoking-Linked Cancer Mutations Mapped

Smoking-Linked Cancer Mutations Mapped

By | November 3, 2016

Scientists produce a detailed genomic map of mutations and epigenetic changes associated with smoking tobacco across 17 tumor types. 

1 Comment

image: Sequencing Reveals Genomic Diversity of the Human Brain

Sequencing Reveals Genomic Diversity of the Human Brain

By | September 16, 2016

Researchers examine the role of long interspersed element-1 retrotransposition in neuronal mosaicism.

4 Comments

image: Monitoring Mitochondrial Mutations

Monitoring Mitochondrial Mutations

By | April 18, 2016

Induced pluripotent stem cells—particularly those generated from older patients—should be screened for defects in mitochondrial DNA, a study shows.

0 Comments

image: Low Mutation Rate in iPSCs

Low Mutation Rate in iPSCs

By | April 11, 2016

The mutation rate in induced pluripotent stem cells is 10 times lower than in somatic cells, scientists show.

0 Comments

image: Mosaic Mutations May Not Be Rare

Mosaic Mutations May Not Be Rare

By | June 5, 2015

Somatic mosaicism may be responsible for a larger proportion of genomic variability within humans than previously thought.

2 Comments

image: Personalized Cancer Vaccines

Personalized Cancer Vaccines

By | April 2, 2015

A dendritic cell vaccine targeting melanoma patients’ tumor-specific mutations can activate a broad range of cancer-fighting T cells. 

2 Comments

image: Stem Cell Divisions Help Explain Cancer Risk

Stem Cell Divisions Help Explain Cancer Risk

By | January 1, 2015

An analysis of 31 tissues finds that random mutations acquired during stem cell divisions correlate with lifetime cancer risk—more so than heritable mutations and environmental factors combined.  

7 Comments

image: Mosaic Mutations

Mosaic Mutations

By | July 31, 2014

Some genetic abnormalities that appear to have sprung up independently in children are in fact present in a portion of their parents’ cells.

3 Comments

image: Mutation Patterns Underlie Cancers

Mutation Patterns Underlie Cancers

By | August 15, 2013

More than 20 genome-wide mutational “signatures” account for the vast majority of 30 common cancers.

2 Comments

Popular Now

  1. Broad Wins CRISPR Patent Interference Case
    Daily News Broad Wins CRISPR Patent Interference Case

    The USPTO’s Patent Trial and Appeal Board has ruled in favor of the Broad Institute of MIT and Harvard retaining intellectual property rights covered by its patents for CRISPR gene-editing technology.

  2. Henrietta Lacks’s Family Seeks Compensation
  3. Humans Never Stopped Evolving
    Features Humans Never Stopped Evolving

    The emergence of blood abnormalities, an adult ability to digest milk, and changes in our physical appearance point to the continued evolution of the human race.

  4. Abundant Sequence Errors in Public Databases
Business Birmingham