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tag drug safety genetics genomics immunology ecology

bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
3D Rendering of Molecular Interaction in CAR Chimeric Antigen Receptor
Next-generation CAR and TCR Cancer Therapies
Danielle Gerhard, PhD | Mar 15, 2024 | 10+ min read
From smart receptors to novel biologics, scientists plan to overcome the challenges of treating solid tumors.
Bugs as Drugs to Boost Cancer Therapy
Danielle Gerhard, PhD | Jan 18, 2024 | 7 min read
Bioengineered bacteria sneak past solid tumor defenses to guide CAR T cells’ attacks.
2022 Top 10 Innovations 
2022 Top 10 Innovations
The Scientist | Dec 12, 2022 | 10+ min read
This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.
An Edith’s checkerspot butterfly
Genome Spotlight: Edith’s Checkerspot Butterfly (Euphydryas editha)
Christie Wilcox, PhD | Aug 25, 2022 | 3 min read
A high-quality genome sequence for this versatile insect will likely aid eco-evolutionary research.
Cas9 enzyme
Molecular Glue ‘Shreds’ Cas9 and Enables a New Form of CRISPR Control
Ida Emilie Steinmark, PhD | Apr 26, 2023 | 3 min read
In a bid to address safety concerns about immune reactions during treatment with CRISPR-based therapeutics, a new technique speeds up how quickly the body destroys the DNA-cutting enzyme Cas9.
Genetically Modified Viral Cocktail Treats Deadly Bacteria in Teen
Ashley Yeager | May 8, 2019 | 2 min read
Tweaking the genomes of two phages and combining them with a third phage helped to clear a persistent Mycobacterium infection in the patient.
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
A fruit bat in the hands of a researcher
How an Early Warning Radar Could Prevent Future Pandemics
Amos Zeeberg, Undark | Feb 27, 2023 | 8 min read
Metagenomic sequencing can help detect unknown pathogens, but its widespread use faces challenges.
Virus Hunters: Searching for Therapeutic Phages in a Drug Resistant World
The Scientist | Sep 21, 2020 | 1 min read
Researchers Jason Gill and Paul Turner will discuss their work on bacteriophage therapy to treat drug resistant bacterial infections.

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