This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.

Drawing inspiration from nature, synthetic biology offers exciting opportunities to transform the future of medicine.

With the help of directed evolution, scientists inch closer to developing viral vectors that can cross the human blood-brain barrier to deliver gene therapy.

Animals with human cells could provide donor organs or help us understand neuropsychiatric disorders.

p53 is possibly the most important protein for maintaining cellular function. Losing it is synonymous with cancer.

Paola Arlotta seeks to understand the complex symphony of brain development in vitro by using organoid models.

Despite a solid understanding of the biological basis of fragile X syndrome, researchers have struggled to develop effective treatments.

We have barely scratched the surface of itch science and what it indicates about our health.

This year’s Breakthrough Prizes honor advances in CAR T cancer therapies, cystic fibrosis, and Parkinson’s disease.

The scientific community bid farewell to researchers who furthered the fields of molecular biology, virology, sleep science, and immunology, among others.