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Juno Therapeutics asks the US Food and Drug Administration for permission to restart the CAR-T experiments without chemotherapy.

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image: Composite Endpoints in Clinical Trials

Composite Endpoints in Clinical Trials

By | July 1, 2016

There’s a right way and a wrong way to boost the statistical sensitivity of this type of clinical studies.

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image: Vaccines Protect Mice Against Zika Infection

Vaccines Protect Mice Against Zika Infection

By | June 29, 2016

Two different vaccines confer complete immunity for two months, researchers report.

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image: NYU Halts Studies, Suspends Investigator

NYU Halts Studies, Suspends Investigator

By | June 28, 2016

Experiments conducted at the New York University School of Medicine violated several research standards, according to US Food and Drug Administration investigators.

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image: Zika Vaccine Ready for Human Trials

Zika Vaccine Ready for Human Trials

By | June 21, 2016

The US Food and Drug Administration has approved a clinical trial to test the vaccine on healthy adults.

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image: Toward Targeted Therapies for Autoimmune Disorders

Toward Targeted Therapies for Autoimmune Disorders

By | June 1, 2016

Training the immune system to cease fire on native tissues could improve outcomes for autoimmune patients, but clinical progress has been slow.

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image: Journal to Publish Clinical Trial Protocols

Journal to Publish Clinical Trial Protocols

By | May 18, 2016

Following an independent group’s finding of misreported outcomes, the Annals of Internal Medicine now requires that authors include clinical trial protocols when submitting their results.

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image: Another Fatal-Disease Drug in Limbo

Another Fatal-Disease Drug in Limbo

By | April 26, 2016

A federal advisory panel votes against Sarepta Therapeutics’s treatment for Duchenne muscular dystrophy.

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image: Two NIH Labs Cease Reagent Production

Two NIH Labs Cease Reagent Production

By | April 20, 2016

Contamination concerns at cell therapy and radioactive tracer facilities spur production shutdowns.

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image: Book Review: <em>Personal Trials</em>

Book Review: Personal Trials

By | March 22, 2016

At first blush, do-it-yourself clinical trials seem pointless and reckless. But a deeper truth pervades the research and the patients who drive it forward.

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