Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.

This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.

Since their introduction to the lab, pluripotent stem cells have gone from research tool to therapeutic, but the journey has been rocky.

Paola Arlotta seeks to understand the complex symphony of brain development in vitro by using organoid models.

Advances in the functional characterization of newly discovered microproteins hint at diverse roles in health and disease.

Thirty years out from the start of the Human Genome Project, researchers have finally finished sequencing the full 3 billion bases of a person’s genetic code. But even a complete reference genome has its shortcomings.

The UCLA geneticist examines how defects in a histone protein lead to symptoms throughout the body.

The author of a new book about emerging concepts in human genetics considers the question.