oncogene

Engineered bacteria sound the alarm on a common oncogenic mutation.

Synonymous mutations have long been ignored in cancer studies since they don’t affect the amino acid sequences of proteins. But research increasingly reveals that they can have disease-driving effects.

Rounds of trial-and-error exploring the layer of cells covering the ovary leave open questions about stem cells that are associated with ovarian cancer.

In the last decade, researchers have come to realize that tumors harbor bits of extrachromosomal DNA that can drive malignancy.

Researchers are uncovering how circular bits of DNA found in some cancer cells can help tumors evolve and kill.

The Harvard Medical School researcher’s work on the genetic basis of protein coding and production led him to make groundbreaking discoveries in immunology, molecular biology, and cancer genetics.

The agency gave personal genomics company 23andMe the green light to screen samples for breast cancer–related genetic mutations.

When transplanted into mice, tumor genomes evolve differently than they do in patients, study finds.

Instructor, Department of Systems Biology, University of Texas MD Anderson Cancer Center. Age: 38

The transcriptional regulator dampens the immune system’s ability to elicit an antitumor response, a study shows.

Chris Marshall, who pieced together a critical signaling pathway involved in cancer, has passed away at age 66.

Charles Sawyers, who began his research career just as the genetic details of human oncogenes were emerging, codeveloped Gleevec, the quintessential targeted cancer therapy.

The tale of p53, a widely studied tumor suppressor gene, illustrates the inventiveness of researchers who turn mishaps into discoveries.

The same microRNAs can have opposing roles in cancer.

If one out of three people develops cancer, that means two others don’t. Understanding why could lead to insights relevant to prevention and treatment.

In Chapter 12, "Of Mice and Men," author Sue Armstrong recounts the point at which researchers moved from working with p53 in tissue culture to studying the gene in animal models.