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A fluorescence image of a lymph node in purple and green
Targeting Antigen “Sanctuary” in Lymph Nodes Could Make Vaccines Better
Researchers find that small sacks inside lymph nodes contain low proteolytic activity and act as safe havens for antigens.
Targeting Antigen “Sanctuary” in Lymph Nodes Could Make Vaccines Better
Targeting Antigen “Sanctuary” in Lymph Nodes Could Make Vaccines Better

Researchers find that small sacks inside lymph nodes contain low proteolytic activity and act as safe havens for antigens.

Researchers find that small sacks inside lymph nodes contain low proteolytic activity and act as safe havens for antigens.

B cells

News feature
Vector image of black body with head surrounded by white clouds
Multiple Possible Causes of Long COVID Come into Focus
Natalia Mesa, PhD | Sep 28, 2022 | 10+ min read
Recent studies have lent support for a variety of hypotheses explaining the debilitating symptoms affecting millions of people after SARS-CoV-2 infection.  
A germinal center inside a lymph node
Slow Vaccine Delivery May Maximize Immune Response
Alejandra Manjarrez, PhD | Sep 23, 2022 | 5 min read
A vaccine strategy involving formulation changes, an initial escalating dose, and a longer wait for booster immunization results in more-effective antibody production against HIV in rhesus monkeys, a study finds.
TSS
Immune Cells and ALS: A Balance Between Life and Death
The Scientist | 1 min read
Understanding the role of immune cells in neurodegeneration may help scientists develop new diagnostic, prognostic, and treatment tools.
COVID-19 vaccine vials
COVID-19 Vaccines Induce Better Long-Term Immunity than Infection
Jennifer Zieba, PhD | Aug 8, 2022 | 3 min read
For the first time, researchers performed a head-to head longitudinal study comparing the immune response elicited by mRNA and traditional COVID-19 vaccines to primary infections.
stained microscope image of a germinal center inside a lymph node
Booster Is Best in the Same Limb as Initial Vaccine: Mouse Study
Alejandra Manjarrez, PhD | May 6, 2022 | 4 min read
Compared to mice who got the doses in separate limbs, animals receiving flu shots in the same paw for both a first and second dose had better-trained memory B cells that bound tighter to the vaccine antigen.
Learn How the Immune System Can Be Trained to Overcome Food Allergies
Retraining the Immune System Cavalry for Food Allergen Peacekeeping Missions
The Scientist | 1 min read
Explore food allergy immunotherapy for reversing patient symptoms.
istock image 800x560
Can mRNA Vaccine Momentum Propel Tumor Immunotherapies?
Aparna Nathan, PhD | Nov 12, 2021 | 4 min read
A guide to mRNA-based cancer vaccines and where they’re headed next
Bispecific Antibodies Treat Cancer in Mouse Models
Abby Olena, PhD | Mar 5, 2021 | 4 min read
A trio of papers shows that specialized antibodies can direct T cells to destroy cells that display portions of mutant cancer-related proteins, as well as T cells that have become cancerous themselves.
Peripheral blood mononuclear cells surrounded by red blood cells in circulating blood.
Accelerating Immune Research with Cryopreserved Peripheral Blood Mononuclear Cells
The Scientist and MilliporeSigma | 3 min read
Commerically-available peripheral blood mononuclear cells offer a well-characterized, accessible, and consistent model for immunology and therapeutic development.
Immunity to SARS-CoV-2 Lasts at Least Six Months, Data Show
Ashley Yeager | Nov 23, 2020 | 4 min read
Half a year after infection, people who had recovered from COVID-19 had robust antibodies, along with traces of the virus in their gut, which may drive long-lasting immunity.
Common Cold Coronaviruses Tied to Less Severe COVID-19 Cases
Anthony King | Nov 11, 2020 | 5 min read
Outcomes in COVID-19 patients may be better in those recently infected with endemic coronaviruses. 
Enhancing the Efficacy of CAR-T Cell Therapies
The Scientist Creative Services Team in Collaboration with IsoPlexis | 1 min read
Jessica Morris will discuss strategies to improve CAR-T cell targeting, activation, and killing capabilities.
Cracking Down on Cancer: A Profile of Owen Witte
Diana Kwon | Apr 1, 2020 | 9 min read
Through his studies on cancer-causing viruses, the University of California, Los Angeles, professor has helped develop lifesaving treatments.
a drop of blood for a newborn's heel is placed on a piece of paper
Gene Therapy Effective for Severe Combined Immunodeficiency
Shawna Williams | Apr 17, 2019 | 4 min read
Researchers report they’ve found a way to restore immune function in infants with one form of “bubble boy disease.”
T Cells: A New Hope for Lasting Protection against SARS-CoV-2
The Scientist | 1 min read
Alessandro Sette and Shane Crotty discuss the T cell response to SARS-CoV-2 and the implications for vaccine design and robust immune memory.
Culprit for Antibody Blockade Identified
Amanda B. Keener | Oct 21, 2016 | 4 min read
Type I interferon organizes several immune mechanisms to suppress B cell responses to a chronic viral infection.
Enhancing Vaccine Development
Wudan Yan | Jun 1, 2016 | 8 min read
Using proteomics methods to inform antigen selection
When the Flu Vax Fails
Jef Akst | Dec 16, 2015 | 2 min read
The status of a person’s immune system can predict when a seasonal flu vaccination will not provide sufficient protection, according to a study. 
B Cells Can Drive Inflammation in MS
Anna Azvolinsky | Oct 21, 2015 | 3 min read
Researchers identify a subset of proinflammatory cytokine-producing B cells that may spark multiple sclerosis-related inflammation.  
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