Most of the human induced pluripotent stem cells stored at major cell line repositories and used in research harbor thousands of DNA errors, a study finds, highlighting the need for improved quality control measures.
Two studies report methods to mimic human fetal brain development using neurons derived from human induced pluripotent stem cells that form 3-D, brain-like structures.
Using CRISPR to swap an archaic variant of the NOVA1 gene into human stem cells, researchers create organoids with neurodevelopmental differences from those carrying modern DNA.
Brianna Chrisman and Jordan Eizenga | Sep 1, 2022 | 10+ min read
Thirty years out from the start of the Human Genome Project, researchers have finally finished sequencing the full 3 billion bases of a person’s genetic code. But even a complete reference genome has its shortcomings.
Clinical trials that target human endogenous retroviruses to treat multiple sclerosis, ALS, and other ailments are underway, but many questions remain about how these sequences may disrupt our biology.
Negative citations; cardiac stem cell saga continues; identifying anonymized genomic study participants; evolution of allergens; a call for biodefense innovation