Displaying an unprecedented dual role for a transcription factor, activating transcription factor 2 (ATF2) also responds to DNA damage, according to Ze'ev Ronai and colleagues at the Burnham Institute in La Jolla, Calif.
Harvard University's Junying Yuan and colleagues identified a chemical that blocks a programmed cell-death pathway that is non-apoptotic.
These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool http://www.facultyof1000.com.J. Roos et al., "STIM1, an essential and conserved component of store-operated Ca2+ channel function," J Cell Biol, 169:435–45, May 9, 2005.This paper reports that STIM1, an integral membrane protein expressed in endoplasmic reticulum (ER) and the plasma membrane, is required for store-operated Ca2+ entry in diverse cell types. An RNAi-based scre
Mice engineered to produce high levels of the antioxidant catalase live longer than their wild-type counterparts.
HIV-1 elicits RNA silencing in human cells, but it also contains a sequence that suppresses the process, according to researchers at the National Institute of Allergy and Infectious Diseases.
© Mike Quinn, Texas Parks & WildlifeResearchers have identified a molecular pathway possibly linking the Monarch butterfly's central circadian clock to photoreceptors involved in its "sun compass," which is used to orient its flight during migration.1 Steven Reppert and colleagues at the University of Massachusetts Medical School performed three experiments focusing on polarized light inputs.They first characterized a specialized dorsal rim area of the Monarch eye that is monochromatic
These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool http://www.facultyof1000.com.S.G. Tringe et al., "Comparative metagenomics of microbial communities," Science, 308:554–7, April 22, 2005.This important paper provides the first comparative analysis of both phylogenetic and functional diversity of entire microbial communities. The communities considered include those associated with farm soils, deep-sea whale carcasses, the S
© 2005 Center for Development BiologyResearchers at the University of Utah are among the first to use large-scale genetics to study the planarian Schmidtea mediterranea, which contains a genome thought to contain insight into adult stem cell pluripotency and tissue regeneration.1Because the organism does not reproduce sexually, it cannot be studied using traditional genetic techniques. But by using bacterial-fed RNA interference against 1065 planarian genes, the study "effectively makes an
In the estimated 5 million years since humans and chimpanzees began diverging, they've acquired major anatomical and cognitive differences.
Researchers at Israel's Weizmann Institute of Science report that lymphocytes rolling on high endothelial venules stop abruptly in response to chemokines presented by endothelial cells.1 Their findings suggest that chemokines stop lymphocytes in a fraction of a second, faster than previously thought.Ronen Alon and colleagues found that chemokines trigger instantaneous extension of the LFA-1 integrin – an adhesion molecule that changes between an inactive, bent conformation and an active, e