Protein aggregates generated in a test tube were found to infect wild-type hamsters with a disease much like scrapie.
The same family of transcription factors directs the epidermal wound repair in mice and flies, according to two research teams.
Researchers at Cornell University's Weill Medical College in New York have created a successful vaccine strategy in mice that uses the immune system's typical antibody response to adenoviruses – which can prevent modified viruses from expressing their payloads and thus diminish the vaccine's efficacy – to boost the antibody response to the vaccine.1By attaching 720 copies of an immunogenic polypeptide from Pseudomonas aeruginosa to the capsid shell of a replication-deficient adenovir
These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool http://www.facultyof1000.com.S.J. Lolle et al., "Genome-wide non-mendelian inheritance of extra-genomic information in Arabidopsis," Nature, 434:505–9, March 24, 2005.This paper reports an unusual form of inheritance in Arabidopsis "hothead" mutants, where DNA sequence information absent in the parent but present in previous generations reappears at high frequency in selfed
Researchers have discovered the first protein quality control system in the yeast nucleus.
National Cancer Institute researcher Eric Huang and colleagues have identified a mechanism that promotes mutations under hypoxic conditions.
The biochemical pathway that senses amino acid deficiencies in yeast is also at work in mammals, according to researchers at the University of California, Davis.
Japanese researchers have identified a sperm protein that is essential for the fusion of the sperm and egg membranes during fertilization.
according to Dutch and German researchers led by Johannes Hackstein of Radboud University Nijmegen in the Netherlands.
Researchers have moved a step forward in understanding how calorie restriction is linked to lifespan extension in mammals.