Proof for prions?
| May 9, 2005
Protein aggregates generated in a test tube were found to infect wild-type hamsters with a disease much like scrapie.
Briefs
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Wound repair in mouse and fly linked
| May 9, 2005
The same family of transcription factors directs the epidermal wound repair in mice and flies, according to two research teams.
Improving vaccines with adenovirus
| April 25, 2005
Researchers at Cornell University's Weill Medical College in New York have created a successful vaccine strategy in mice that uses the immune system's typical antibody response to adenoviruses – which can prevent modified viruses from expressing their payloads and thus diminish the vaccine's efficacy – to boost the antibody response to the vaccine.1By attaching 720 copies of an immunogenic polypeptide from Pseudomonas aeruginosa to the capsid shell of a replication-deficient adenovir
Interdisciplinary Research
April 25, 2005
These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool http://www.facultyof1000.com.S.J. Lolle et al., "Genome-wide non-mendelian inheritance of extra-genomic information in Arabidopsis," Nature, 434:505–9, March 24, 2005.This paper reports an unusual form of inheritance in Arabidopsis "hothead" mutants, where DNA sequence information absent in the parent but present in previous generations reappears at high frequency in selfed
Quality control in the nucleus
| April 25, 2005
Researchers have discovered the first protein quality control system in the yeast nucleus.
hinders mismatch repair
| April 11, 2005
National Cancer Institute researcher Eric Huang and colleagues have identified a mechanism that promotes mutations under hypoxic conditions.
Mammals feed off yeast pathway
| April 11, 2005
The biochemical pathway that senses amino acid deficiencies in yeast is also at work in mammals, according to researchers at the University of California, Davis.
Sperm fusion protein identified
| April 11, 2005
Japanese researchers have identified a sperm protein that is essential for the fusion of the sperm and egg membranes during fertilization.
Evidence for organelle origin
| March 28, 2005
according to Dutch and German researchers led by Johannes Hackstein of Radboud University Nijmegen in the Netherlands.
Fast track to longevity
| March 28, 2005
Researchers have moved a step forward in understanding how calorie restriction is linked to lifespan extension in mammals.
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