These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool http://www.facultyof1000.com.J.F. Roeth et al., "HIV-1 Nef disrupts MHC-I trafficking by recruiting AP-1 to the MHC-I cytoplasmic tail." J Cell Biol, 167:903–13, Dec. 6, 2004.This study defines a novel pathway by which immune evasion protein Nef of HIV-1 traffics MHC-I proteins in T cells from the trans-Golgi network (TGN) to the lysosome for degradation. Indeed, the authors
by an RNA polymerase that acts as a liaison between both pathways, according to UK researchers.
), governs axon and dendrite growth in determining cell polarity, according to research groups from China and Japan.
Researchers at deCODE Genetics in Reykjavik, Iceland, have discovered a large chromosomal rearrangement in the human genome that appears to have been selected for in some European populations.1The rearrangement, a 900-kilobase inversion polymorphism at chromosome 17q21.31, appears in two lineages, H1 and H2, that have diverged for as many as 3 million years with no evidence of having recombined. The H2 lineage – rare in Africans, almost nonexistent in East Asians, but found in 20% of Europ
, an ancient protist long considered to be asexual, may have a sex life.
These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature awareness tool http://www.facultyof1000.com.S.E. Williams et al., "Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel," Science, 306:2093-7, Dec. 17, 2004.It was known that [Big K+] channels are sensitive to oxygen, but the mechanism of sensing oxygen has remained elusive. It appears now that hemoxygenase-2 is in a complex with BK channels, and that carbon monoxide, a p
RNA interference (RNAi) takes place in the nuclei of human cells, according to a group from the University of Massachusetts Medical School.
Statin drugs appear to reduce inflammation associated with Alzheimer disease (AD) in a cholesterol-independent manner, say researchers from Case Western Reserve University, Cleveland.
For the first time, scientists have described a way for cells to add phosphate groups to proteins that doesn't involve an ATP donor.
These papers were selected from multiple disciplines from the Faculty of 1000, a Web-based literature-awareness tool http://www.facultyof1000.com.R. Ando et al., "Regulated fast nucleocytoplasmic shuttling observed by reversible protein highlighting," Science, 306:1370-3, Nov. 19, 2004.The authors describe a new fluorophore (Dronpa) that has a high quantum yield as well as being remarkably photochromic. Dronpa can be interconverted between bright (fluorescent) and dark (nonfluorescent) states by