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Factor tracker

By | October 1, 2008

Credit: Thomas Splettstoesser / wikimedia.org" /> Credit: Thomas Splettstoesser / wikimedia.org The paper: C.-L. Wei et al., "A global map of p53 transcription-factor binding sites in the human genome," Cell, 124:207-19, 2006. (Cited in 184 papers) The technique: Yijun Ruan, of the Genome Institute of Singapore, and colleagues wanted a better way to study where transcription factors (TFs) bind to DNA. They deve

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Choosy cortex

By | September 1, 2008

Credit: brainmaps.org" /> Credit: brainmaps.org The paper: C. Padoa-Schioppa & J.A. Assad, "Neurons in the orbitofrontal cortex encode economic value," Nature, 441:223-6, 2006. (Cited in 76 papers) The finding: Researchers from Harvard Medical School measured neuronal firing rates in macaques who had been offered different juice rewards. By varying the amounts and types of

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Mysterious resistance

By | September 1, 2008

Credit: brainmaps.org" /> Credit: brainmaps.org The paper: G. A. Jacoby et al. "qnrB, another plasmid-mediated gene for quinolone resistance," Antimicrob Agents Chemother, 50:1178-82, 2006. (Cited in 65 papers) The finding: Eight years after discovering qnrA, the first plasmid-mediated gene for resistance to the broad-spectrum antibiotic quinolone, George Jacoby of the

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Apoptosis at bay

By | August 1, 2008

Credit: © Dr Gopal Murti / Photo Researchers, Inc." /> Credit: © Dr Gopal Murti / Photo Researchers, Inc. The paper: M. Certo et al., "Mitochondria primed by death signals determine cellular addiction to anti-apoptotic BCL-2 family members," Cancer Cell, 9:351-65, 2006. (Cited in 116 papers) The finding: Anthony Letai's team at the Dana-Farber Cancer Institute

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Dr. Autophagy to the ER

By | August 1, 2008

Credit: © Professors Pietro M. Motta & Tomonori Naguro / Photo Researchers, Inc." /> Credit: © Professors Pietro M. Motta & Tomonori Naguro / Photo Researchers, Inc. The paper: T. Yorimitsu et al., "Endoplasmic reticulum stress triggers autophagy," J Bio Chem, 281:30299-304, 2006. (Cited in 48 papers) The finding: Universit

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Microbes to the max

By | August 1, 2008

Credit: Courtesy of Jed Fuhrman / University of Southern California" /> Credit: Courtesy of Jed Fuhrman / University of Southern California The paper: M.L. Sogin et al., "Microbial diversity in the deep sea and the underexplored 'rare biosphere,'" Proc Nat Acad Sci, 103:12115-20, 2006. (Cited in 81 papers) The finding: In 2006, Mitchell Sogin of the Marine Biological La

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A mini modification

By | July 1, 2008

Credit: © Biophoto Associates / Photo Researchers, Inc." /> Credit: © Biophoto Associates / Photo Researchers, Inc. The paper: M. Shogren-Knaak et al., "Histone H4-K16 acetylation controls chromatin structure and protein interactions." Science, 311:844-7, 2006. (Cited in 132 papers) The finding: Craig Peterson's group at the University of Massachusetts Medical

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Caution: RNAi

By | July 1, 2008

Credit: © Biophoto Associates / Photo Researchers, Inc." /> Credit: © Biophoto Associates / Photo Researchers, Inc. The paper: D. Grimm et al., "Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways," Nature, 441:537-41, 2006. (Cited in 147 papers) The finding: While studying the potential of RNA interference (RNAi) to treat he

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Mapping methylation

By | July 1, 2008

Credit: © Cell Press" /> Credit: © Cell Press The paper: X. Zhang et al., "Genome-wide high-resolution mapping and functional analysis of DNA methylation in Arabidopsis," Cell, 126:1189-201, 2006. (Cited in 94 papers) The finding: The researchers created a Web tool to view the DNA methylation and gene expression data. "It's extremely useful,"

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Human selection

By | June 1, 2008

Credit: Courtesy of Jonathan Pritchard / Public Library of Science" /> Credit: Courtesy of Jonathan Pritchard / Public Library of Science The paper: B.F. Voight et al., "A map of recent positive selection in the human genome," PLoS Biology, 4:446-58, 2006. (Cited in 138 papers) The finding: In 2006, Jonatha

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