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image: Epigenetics of Trained Innate Immunity

Epigenetics of Trained Innate Immunity

By | September 25, 2014

Documenting the epigenetic landscape of human innate immune cells reveals pathways essential for training macrophages.

2 Comments

image: Epigenetic Changes Can Cause Cancer

Epigenetic Changes Can Cause Cancer

By | July 25, 2014

A transgene designed to attract methylation to the promoter of a tumor-suppressor gene leads to tumorigenesis in a mouse model. 

4 Comments

image: A Multi-Cancer Diagnostic?

A Multi-Cancer Diagnostic?

By | July 14, 2014

Researchers report an ability to detect several types of cancer in blood samples based on signatures of immune response, but some are skeptical about the utility of such a test.

3 Comments

image: Targeted Brain Cancer Vaccine

Targeted Brain Cancer Vaccine

By | June 25, 2014

Mouse study demonstrates the ability of a cancer vaccine targeted against a specific oncogenic mutation to elicit a protective anti-tumor immune response. 

1 Comment

image: Protein Clumps Spread Inflammation

Protein Clumps Spread Inflammation

By | June 22, 2014

ASC specks—protein aggregations that drive inflammation—are released from dying immune cells, expanding the reach of a defense response.

1 Comment

Scientists generate tumor-targeting molecules that can be used for imaging and treatment.

0 Comments

image: Ancient Apoptosis

Ancient Apoptosis

By | June 9, 2014

Humans and coral share a cell-death pathway that has been conserved between them for more than half a billion years.

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image: Making Sense of the Tumor Exome

Making Sense of the Tumor Exome

By | May 18, 2014

An algorithm can pick out biologically and clinically meaningful variants from whole-exome sequences of tumors.

0 Comments

image: Obesity Complicates Colorectal Cancer

Obesity Complicates Colorectal Cancer

By | April 9, 2014

Study finds that prediagnosis obesity is predictive of poor prognosis, even among patients who have a molecular marker associated with better disease outcome.

1 Comment

image: Epigenetic Cancer Therapy Clears Phase I

Epigenetic Cancer Therapy Clears Phase I

By | April 7, 2014

Investigational drug that inhibits proteins involved with epigenetic regulation shows activity against certain blood cancers in an early-stage clinical trial.

0 Comments

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