Nicole Johnston | Nov 10, 2002 | 6 min read
Graphic: Courtesy of Scott Stevens ASSEMBLY INSTRUCTIONS: In the penta-snRNP model, all five spliceosomal snRNPs interact with the substrate pre-mRNA as a single, discrete particle. Spliceosome assembly in yeast extracts also could occur by interaction of the U1 snRNP with the pre-mRNA, followed by a tetra-snRNP joining to form a functionally identical particle. (Reprinted with permission from Elsevier Science, Molecular Cell, 9:31-4, 2002.) In multicellular organisms, the earliest prod