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Adeno-associated viruses
Strategies for Smuggling Gene Therapies Past the Immune System
Researchers are devising ways to prevent viral vectors carrying gene therapies from triggering an immune response.
Strategies for Smuggling Gene Therapies Past the Immune System
Strategies for Smuggling Gene Therapies Past the Immune System

Researchers are devising ways to prevent viral vectors carrying gene therapies from triggering an immune response.

Researchers are devising ways to prevent viral vectors carrying gene therapies from triggering an immune response.

disease & medicine, immunology

Virologist Keerti Shah Dies
Catherine Offord | Aug 2, 2019 | 3 min read
The Johns Hopkins University researcher’s work helped solidify the link between human papillomavirus and cervical cancer, leading to the approval of the HPV vaccine in 2006.
Does the Microbiome Help the Body Fight Cancer?
Catherine Offord | Jul 10, 2019 | 4 min read
Research in mice and humans is beginning to establish a link between the composition of microbes in the gut and immune responses to tumor cells, but the mechanisms are not yet clear.
Q&A: Myth Debunkers Take Aim at Microbiology Lore
Ashley Yeager | Jun 25, 2019 | 4 min read
University of Michigan’s Ada Hagan separates fact from fiction, such as whether you should starve a fever or if eating chocolate really causes acne.
Pioneering Immunologist Teruko Ishizaka Dies
Ashley Yeager | Jun 14, 2019 | 2 min read
With her husband, she studied allergic reactions and identified antibodies that set off itching, wheezing, and rashes.
taming the beast the scientist
Could Tolerating Disease Be Better than Fighting It?
Ashley Yeager | Jun 1, 2019 | 10+ min read
Quieting immune attacks against pathogens and even providing nutrients to the invaders could improve health, according to a new line of research.
Commensal Mimicry in Autoimmune Disease
Infographic: Commensal Mimicry in Autoimmune Disease
Amanda B. Keener | Jun 1, 2019 | 1 min read
Antigens originating from the microbiome may trigger an autoimmune response.
disease tolerance infographic banner
Infographic: Immunity Isn’t the Body’s Only Defense System
Ashley Yeager | Jun 1, 2019 | 3 min read
Symbiotic bacteria, metabolism, and stress pathways can all help animals tolerate, rather than succumb, to disease.
Genetically Modified Viral Cocktail Treats Deadly Bacteria in Teen
Ashley Yeager | May 8, 2019 | 2 min read
Tweaking the genomes of two phages and combining them with a third phage helped to clear a persistent Mycobacterium infection in the patient.
peanut allergy anaphylaxis oit oral immunotherapy
Peanut Allergy Immunotherapy Increases Anaphylaxis Risk: Study
Kerry Grens | Apr 26, 2019 | 2 min read
Although the oral treatment seems to work, an analysis of the results from 12 clinical trials finds kids who got an immunotherapy have a greater rate of serious reactions.
t cell b cell lymphoma car t-cell therapy chimeric antigen receptor
A Revised CAR T for Lymphoma Has Fewer Side Effects
Kerry Grens | Apr 23, 2019 | 2 min read
An early-stage clinical study finds that none of the 25 patients treated developed neurotoxicity or cytokine release syndrome, common hazards of the cancer immunotherapy.
a drop of blood for a newborn's heel is placed on a piece of paper
Gene Therapy Effective for Severe Combined Immunodeficiency
Shawna Williams | Apr 17, 2019 | 4 min read
Researchers report they’ve found a way to restore immune function in infants with one form of “bubble boy disease.”
tuft cell lungs mice solitary chemosensory cells SCC
Image of the Day: Tuft Cells
Chia-Yi Hou | Apr 3, 2019 | 1 min read
After a severe case of flu, mice have chemosensory cells in their lungs, a place where they don’t normally occur.
CAR Ts solid tumor
The Next Frontier of CAR T-Cell Therapy: Solid Tumors
Kerry Grens | Apr 1, 2019 | 10+ min read
The technology has wowed the field by all but obliterating some patients’ blood cancers, but solid malignancies present new challenges.
car t cell infographic april 2019 the scientist solid tumor liquid cancer
Infographic: CAR-T Cells in Solid Versus Liquid Cancers
Kerry Grens | Apr 1, 2019 | 2 min read
Tumor accessibility, heterogeneity, and microenvironment vary between the two classes of malignancies.
CAR T Cells Treat Lupus in Mice
Abby Olena, PhD | Mar 6, 2019 | 3 min read
T cells modified to target disease-contributing B cells improved survival in two mouse models of the autoimmune disease.
Long-Term HIV Remission After Medicine Discontinued
Kerry Grens | Mar 5, 2019 | 2 min read
The “London patient” may represent the second person cured of the infection by a cell transplant.
Salt Could Play a Role in Allergies
Abby Olena, PhD | Feb 20, 2019 | 3 min read
High salt concentrations are present in the affected skin of people with atopic dermatitis and promote the differentiation of the T helper cells involved in the development of allergic diseases.
Climate Change May Hamper Response to Flu: Study
Carolyn Wilke | Feb 5, 2019 | 2 min read
Mice exposed to heat wave temperatures ate less and showed weakened immune responses to the virus.
Image of the Day: Gut Reaction
Carolyn Wilke | Feb 4, 2019 | 1 min read
Immune cells in the mouse gut help recognize damaging compounds and prompt intestinal stem cells to repair DNA.
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