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Cigall Kadoch Unravels Chromatin’s Role in Cancer
Cigall Kadoch Unravels Chromatin’s Role in Cancer
The Dana-Farber Cancer Institute researcher is developing cancer therapeutics based on how the physical structure of DNA contributes to the disease.
Cigall Kadoch Unravels Chromatin’s Role in Cancer
Cigall Kadoch Unravels Chromatin’s Role in Cancer

The Dana-Farber Cancer Institute researcher is developing cancer therapeutics based on how the physical structure of DNA contributes to the disease.

The Dana-Farber Cancer Institute researcher is developing cancer therapeutics based on how the physical structure of DNA contributes to the disease.

genetics & genomics, cancer

MyHeritage Launches Health-Related Genetic Test, Ignites Debate
Catherine Offord | Jul 9, 2019 | 8 min read
Its screen for selected variants of some disease-linked genes gives customers an incomplete picture of their risk—do they know?
Even Healthy Tissues Carry Clusters of Cells with Mutations: Study
Ashley Yeager | Jun 7, 2019 | 2 min read
Most of the genetic alterations are harmless, but some may contribute to cancer.
sperm epigenetics cancer risk heritability histones
Mice Inherit Cancer Susceptibility Via Epigenetic Changes in Sperm
Emma Yasinski | Apr 19, 2019 | 3 min read
Mouse fathers whose sperm lacks the gene Kdm6a pass down altered methylation patterns to male offspring, along with a better chance of developing tumors and dying.
nancy davidson fred hutch epigenetics breast cancer
Q&A: Epigenetic Therapies for Breast Cancer
Katarina Zimmer | Apr 4, 2019 | 4 min read
Breast cancer researcher and oncologist Nancy Davidson discusses what we’ve learned from the first wave of epigenetic trials for breast cancer, and what challenges lie ahead before such therapies reach the clinic.
exosome cancer liver hepatocellular carcinoma RNA cirrhosis
Exosomes from Blood Carry RNA Signatures of Liver Cancer
Emma Yasinski | Apr 2, 2019 | 2 min read
A small study finds that the tiny extracellular vesicles from patients with hepatocellular carcinoma have RNA content distinct from patients with cirrhosis only.
Q&A: A 10,000-Genome Milestone for Shared Pediatric Cancer Data  
Carolyn Wilke | Apr 1, 2019 | 3 min read
Computational biologist Jinghui Zhang of St. Jude realized scientists could work more efficiently with tools and genomic data shared on the cloud.
april 2019 crossword
Ten-Minute Sabbatical
The Scientist | Apr 1, 2019 | 2 min read
Take a break from the bench to puzzle and peruse.
primordial germ cells
Stray Germ Cells May Seed Female-Biased Cancerous Cysts
Ashley Yeager | Apr 1, 2019 | 2 min read
Similarities in gene expression hint at the origin of a certain type of pancreatic tumor that predominantly afflicts women.
cancer more common in men
Why Is Cancer More Common in Men Than in Women?
Jef Akst | Apr 1, 2019 | 4 min read
The molecular processes that lead males to be more susceptible to the disease are only beginning to come to light.
Cancer-Specific Antigens Encoded in “Junk” DNA
Carolyn Wilke | Apr 1, 2019 | 2 min read
Researchers found that allegedly noncoding genetic material carries the instructions for many peptides that may help harness the immune system to fight cancer.
More Cancer Mutations, Better Immunotherapy Outcomes
Catherine Offord | Jan 15, 2019 | 2 min read
Immune checkpoint inhibitors are generally most effective against tumors with more genetic mutations, according to a new study, although the relationship isn’t true for all cancers.
Eli Lilly Will Buy Loxo Oncology for $8 Billion
Ashley Yeager | Jan 8, 2019 | 2 min read
Loxo focuses on cancer treatments based on tumor genetics, which will contribute to Lilly’s push in the cancer drug space.
Genome, Exome, RNA Sequencing Applied to Pediatric Cancer Cases
Ashley Yeager | Oct 18, 2018 | 2 min read
Combining data from the genetic testing techniques can guide patient care, scientists say.
Thousands of BRCA1 Genetic Variants Functionally Characterized
Sukanya Charuchandra | Sep 13, 2018 | 2 min read
The researchers catalogued 3,893 variants of the gene implicated in cancer using CRISPR.
Elephants Revived a “Zombie” Gene that May Fend Off Cancer
Kerry Grens | Aug 15, 2018 | 1 min read
DNA damage kick-starts what was once a defunct duplicated gene, which kills off injured cells.
Cancer Geneticist Quits After Harassment Allegations
Kerry Grens | Jul 17, 2018 | 1 min read
Accusations that Nazneen Rahman bullied employees at the Institute of Cancer Research in the U.K. stretch back 12 years.
CRISPR Gene Editing Deletes, Shuffles More Genes than Intended
Ashley Yeager | Jul 16, 2018 | 2 min read
The DNA-cutting enzyme used in the technique is not as precisely targeted as scientists had thought, and investors take notice.
Artificial Intelligence to Boost Liquid Biopsies
Claire Asher | Jun 26, 2018 | 4 min read
Machine-learning algorithms tuned to detecting cancer DNA in the blood could pave the way for personalized cancer care.
CRISPR Efficiency Tied to Cancer-Causing Process
Kerry Grens | Jun 11, 2018 | 2 min read
Two studies find the genome-editing technique works best when cells have a faulty DNA-damage response that’s frequently present in cancers.  
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