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Breast cancer linked to chromatin remodeling

By | July 31, 2000

BRCA1 is a tumor-suppressor gene linked to familial breast and ovarian cancers. In the July 21 Cell, Bochar et al. find that the predominant BRCA1-containing complex in human cells is the SWI/SNF-related chromatin remodeling complex (Cell 2000, 102:257-265). This may explain the multitude of properties that have been ascribed to BRCA1, including effects on transcription, DNA repair, and cell-cycle checkpoints. Mutations in SNF5, another subunit of the SWI/SNF complex, have been shown to result i

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NEW YORK, July 26 (Praxis Press) Depression and anxiety are associated with diminished health status and increased health care utilization, but whether patients with these disorders are less likely than other patients to comply with medical treatment recommendations is unclear. DiMatteo and colleagues performed an analysis of studies catalogued on MEDLINE and PsychLit from January 1, 1968, through March 31, 1998 and included studies if they measured patient compliance and depression or anxiety.

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Diabetes and exercise

July 31, 2000

NEW YORK, July 26 (Praxis Press) Regular physical activity is independently associated with a reduction in the risk of major coronary heart disease (CHD) events and type 2 diabetes. However, few prospective studies have investigated the role of insulin as a mediating factor in the relationship between physical activity and CHD or type 2 diabetes. To examine this relationship, Wannamethee and colleagues performed a prospective study of 5,159 men aged 40 to 59 years with no history of CHD, type 2

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NEW YORK, July 26 (Praxis Press) Hormone replacement therapy (HRT) is a possible alternative to parathyroidectomy in the treatment of hyperparathyroidism, but the efficacy of HRT in the long-term treatment of chronic stable primary hyperparathyroidism is unclear. To assess this, Orr-Walker and colleagues performed a randomized, placebo-controlled trial of 23 postmenopausal women with primary hyperparathyroidism over the course of 2 to 4 years. Of the 23 women, 11 received HRT and 12 received pla

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Influenza vaccine delay

July 31, 2000

Delays in distribution of influenza vaccine expected this season.

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Nesiritide and CHF

July 31, 2000

NEW YORK, July 27 (Praxis Press) Intravenous infusion of nesiritide, a brain (B-type) natriuretic peptide, has beneficial hemodynamic effects in patients with decompensated congestive heart failure (CHF). Colucci and colleagues assessed the clinical use of nesiritide in CHF patients to evaluate symptomatic endpoints. Patients hospitalized because of symptomatic CHF were enrolled in either an efficacy trial or a comparative trial. In the efficacy trial, 127 patients were randomly assigned to doub

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Prepackaged diet

July 31, 2000

NEW YORK, July 27 (Praxis Press) Roughly 55% of persons aged 20 years or older in the United States are obese or overweight and weight reduction remains the first-line treatment strategy. Metz and colleagues assessed the long-term effects of two types of diet: a prepackaged, nutritionally complete, prepared meal plan and a usual-care diet (UCD), based on patient choices made from an approved list of substitutions. They compared the effects of the two diets on weight loss and cardiovascular risk

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Restless legs syndrome

July 31, 2000

NEW YORK, July 26 (Praxis Press) Treatment for restless legs syndrome (RLS) is available, but most instances of RLS may remain undiagnosed. To determine the prevalence and health status correlates of symptoms of RLS in the general population Phillips and colleagues interviewed 1,803 men and women, 18 years and older as part of the 1996 Kentucky Behavioral Risk Factor Surveillance Survey. They found that 3% of participants aged 18 to 29 years, 10% of those aged 30 to 79 years, and 19% of those 80

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Surgery for emphysema

July 31, 2000

NEW YORK, July 27 (Praxis Press) Lung-volume-reduction surgery is thought to improve lung function, walking distance, and quality of life in patients with severe emphysema, but the benefits of this surgery over standard medical treatment have not been rigorously studied. To compare this procedure with continuing medical treatment Geddes and colleagues studied patients randomized to received surgery (n=24) or continued medical treatment (n=24). Of the patients, five in the surgical group and thre

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West Nile virus

July 31, 2000

NEW YORK, July 28 (Praxis Press) In late August 1999, an outbreak of encephalitis caused by West Nile virus (WNV) was detected in New York City and in neighboring counties. As a result, in May 2000, the Centers for Disease Control and Prevention (CDC) issued guidelines and provided funds to support mosquito-control and risk-reduction campaigns and surveillance in 19 states where WNV transmission had occurred or would likely occur. A new report by the CDC states that from May 6 through July 8, 20

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