Research round-up

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Pravastatin and stroke

August 8, 2000

Pravastatin may lower stroke risk in patients with coronary artery disease.

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Smoking cessation

August 8, 2000

NEW YORK, August 7 (Praxis Press) By 1950, about 80% of men and 40% of women in the United Kingdom smoked, but decades would pass before the health effects of long-term smoking and smoking cessation could be quantified. Peto and colleagues studied national trends in smoking prevalence and lung cancer rates. The epidemiologic study included hospitalized patients with and without lung cancer in 1950 and 1990; it also included 1,465 case-control pairs from the 1950 study and 982 cases and 3,185 con

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NEW YORK, August 3 (Praxis Press) The antipsychotic drug, Mellaril (thioridazine) has been shown to prolong patients' QTc interval, which can lead to a type of ventricular tachycardia known as torsades de pointes and potentially sudden death. At the request of the US Food and Drug administration (FDA), the manufacturer of the drug, Novartis, has now added a black box warning on the drug's label in order to alert physicians to its tendency of prolonging a patient's heartbeat interval. Now Mellari

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Thrombolytic therapy

August 8, 2000

NEW YORK, August 7 (Praxis Press) Thrombolytic therapy for acute myocardial infarction is equally effective when delivered as a bolus injection and as a 60 to 90-minute infusion; however, the relative safety of these two delivery methods is unknown. Using meta-analysis, Mehta and colleagues studied the risk of intracranial hemorrhage in patients receiving thrombolytic therapy as a bolus or as an infusion. The analysis included seven randomized trials with a total of 103,972 patients. The risk of

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Recommend a tuberculin skin test to patients returning from regions where tuberculosis is endemic.

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Breeding a better vector

By | August 7, 2000

DNA shuffling (also called molecular breeding) generates variation by random fragmentation of a cloned gene followed by reassembly of the fragments in a self-priming polymerase reaction. The result is a recombination of overlapping fragments that have different mutations or come from different, naturally occurring homologous genes. In the August Nature Genetics Soong et al apply this technique to a pool of six different murine leukemia virus envelope sequences to derive a new virus that can,

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Profiles of metastasis

By | August 7, 2000

DNA microarray analysis of metastatic cells reveals a new player, and an expression profile characteristic of reduced motility and invasive ability.

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The two chromosomes of cholera

By | August 7, 2000

suggests that the bacterium's second chromosome may have started life as a megaplasmid.

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Better evaluation of health risks associated with cell phones is necessary.

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Esophageal adenocarcinoma

August 3, 2000

Reflux-promoting drugs may raise risk for esophageal adenocarcinoma.

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