My “colleagues” and I at the fictitious Arthur Vandelay Urological Research Institute were surprised to find our bogus “uromycitisis” case report swiftly accepted, with only minor revisions requested.
August 7, 2000|
DNA shuffling (also called molecular breeding) generates variation by random fragmentation of a cloned gene followed by reassembly of the fragments in a self-priming polymerase reaction. The result is a recombination of overlapping fragments that have different mutations or come from different, naturally occurring homologous genes. In the August Nature Genetics Soong et al apply this technique to a pool of six different murine leukemia virus envelope sequences to derive a new virus that can,