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NEW YORK, July 17 (Praxis Press) Studies suggest that cardiomyocytes undergo apoptosis after myocardial infarction (MI), and characterization of the extent and timeline of this phenomenon might help tailor new therapeutic interventions. Hofstra and colleagues studied the uptake of technetium-99m-labelled annexin-V in the myocardium of patients with acute MI (see paper). In six of seven patients, labeled annexin-V was taken up by the infarct area only, and this area corresponded to a perfusion de

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NEW YORK, July 17 (Praxis Press) Magnetic resonance cholangiopancreatography (MRCP) is a promising alternative to endoscopic retrograde cholangiopancreatography (ERCP), but its accuracy has not been proven in a large controlled study. Adamek and colleagues prospectively compared MRCP and ERCP for the differentiation of pancreatic lesions in 124 patients with suspected pancreatic cancer (see paper). For the diagnosis of pancreatic cancer, MRCP had a sensitivity of 84% and a specificity of 97%, wh

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Prophylactic mastectomy

July 21, 2000

NEW YORK, July 19 (Praxis Press) Prophylactic mastectomy is a preventive option for women who wish to reduce their risk of breast cancer but the psychological and social consequences of this procedure is unclear. To evaluate patients' long-term satisfaction and psychological and social function following prophylactic mastectomy, Frost and colleagues surveyed 572 women undergoing bilateral prophylactic mastectomy (see paper). The questionnaire was designed to evaluate satisfaction with the proced

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Sprue and T cells

July 21, 2000

NEW YORK, July 17 (Praxis Press) The cellular abnormalities and long-term prognosis of refractory sprue are largely unknown. Cellier and colleagues studied the phenotypic and molecular features of intraepithelial T cells in patients with refractory sprue (see paper). Analysis of intestinal tissue revealed an aberrant intraepithelial lymphoid population and T-cell receptor gene rearrangements in most patients. Patients with aberrant lymphocytes had a poorer prognosis, and some developed overt T-c

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Stress test in elderly

July 21, 2000

NEW YORK, July 19 (Praxis Press) Physical activity benefits older persons but current guidelines for exercise stress-testing may not apply to the majority of persons aged 75 years or older. Gill and colleagues suggest that the guidelines call for prohibitively expensive and unnecessary tests to monitor heart function and could deter the elderly from beginning an exercise program (see paper). To clarify this hypothesis, the researchers analyzed several studies supporting the benefits and risks of

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NEW YORK, July 17 (Praxis Press) Maternal toxoplasmosis can have devastating consequences for the baby; however, the main risk factors associated with this infection have not been well defined. In a European case-control study, Cook and colleagues evaluated the role of food and environmental factors in acute toxoplasmosis among pregnant women (see paper). Eating undercooked and cured meat accounted for 30% to 63% of infections at the six study centers; other significant risk factors included soi

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Triple therapy safety

July 21, 2000

NEW YORK, July 18 (Praxis Press) Multidrug antiretroviral therapy has decreased the morbidity and mortality associated with human immunodeficiency virus (HIV) infection, but the long-term effects and safety of this treatment are unknown. Gulick and colleagues studied the durability and toxicity associated with combined indinavir, zidovudine and lamivudine therapy in HIV-infected patients (see paper). Almost 65% of patients continued therapy for three years. Serum viral loads remained suppressed

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launches first paper

By | July 20, 2000

's first peer reviewed and accepted paper is published this week.

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Rice - the prequel

By | July 20, 2000

Researchers hoping to decipher the first complete genome sequence of a plant fear the lengthy clusters of repeated transposon sequences present in many plant genomes. But in the July issue of Genome Research, Mao et al. report promising news for the international consortium tackling the rice genome (Genome Res. 2000, 10:982-990). After sequencing 73,000 DNA fragments distributed through the rice genome (a total of nearly 50 Mb), Mao et al. find that less than 10% of the sequences contain transpo

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Simulated fly segmentation

By | July 19, 2000

A compendium of expression profiles from mutant yeast strains allows function to be attributed to uncharacterized genes and leads to the identification of a drug target.

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