Academic research could be strengthened by thinking more and doing less.
July 21, 2000
NEW YORK, July 17 (Praxis Press) The cellular abnormalities and long-term prognosis of refractory sprue are largely unknown. Cellier and colleagues studied the phenotypic and molecular features of intraepithelial T cells in patients with refractory sprue (see paper). Analysis of intestinal tissue revealed an aberrant intraepithelial lymphoid population and T-cell receptor gene rearrangements in most patients. Patients with aberrant lymphocytes had a poorer prognosis, and some developed overt T-c