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Stress-induced recombination

By | February 19, 2002

The stress of pathogenic attack can stimulate somatic recombination in plants.

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Chromosome conformation

By | February 18, 2002

In the February 15 Science, Dekker et al. describe an ingenious high-throughput method to analyse the spatial organization and physical properties of whole chromosomes (Science 2002, 295:1306-1311).They call their technique 'chromosome conformation capture' (3C); it involves the isolation of intact nuclei, followed by formaldehyde fixation which causes cross-linking of genomic segments that are in contact via their DNA-bound proteins. The cross-linking frequencies can then be measured by restric

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Gonococcal immune suppression

By | February 18, 2002

Patients infected with Neisseria gonorrhoea present with intense inflammation resulting in urethral or cervical pus discharge, but the specific immune response to the bacteria is weak and does not protect against subsequent gonococcal infections. In February 19 online Nature Immunology, Ian Boulton and Scott Gray-Owen from University of Toronto, Canada, show that N. gonorrhoea have a mechanism that can arrest the activation and proliferation of CD4+ T lymphocytes via the CEACAM1 adhesion molecul

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Cash boost for research access

By | February 15, 2002

The campaign for freedom of access to scientific research has been given a $3 million boost.

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Diagnosing cancer with artificial neural networks

By | February 15, 2002

Artificial neural networks can efficiently distinguish human subtypes of neoplastic colorectal lesions.

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Viruses on the brain

By | February 15, 2002

Viral delivery of Cre recombinase can result in genetic engineering in the nervous system of adult mice.

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Premature death

By | February 14, 2002

Although mice cloned by somatic-cell nuclear transfer appear relatively normal, the long-term consequences of cloning are now becoming apparent. In an Advanced Online Publication from Nature Genetics, Ogonuki et al. report that cloned mice die earlier than normal animals (Nat Gen 2002, DOI:10.1038/ng841).They followed 12 male mice cloned from immature Sertoli cells, together with genetically matched controls and mice generated by spermatid injection. The cloned mice grew normally, but they began

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Suicide gene therapy for colon cancer

By | February 14, 2002

Injection of suicide gene modified tumor cells induces a systemic antitumor response in a rat model of metastatic colon carcinoma.

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Building brand new kidneys

By | February 13, 2002

Advanced Cell Technology has sparked yet more controversy with its claim to have grown kidney-like organs.

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Cloning from lymphocytes

By | February 13, 2002

Cloning animals from nuclei that are genetically marked by terminal differentiation remains inefficient, with most clones dying during gestation. In February 10 online Nature, Konrad Hochedlinger and Rudolf Jaenisch from Massachusetts Institute of Technology, Cambridge, USA, show that monoclonal mice can be generated by nuclear transfer from mature B and T donor cells. Hochedlinger & Jaenisch transferred nuclei from peripheral lymph node cells of mice into enucleate oocytes. From the resulti

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