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Biomarker for Alzheimer's disease

By | March 27, 2002

efflux may be used as a measure of brain amyloid load in Alzheimer's disease.

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Cesar Milstein dies

By | March 27, 2002

sar Milstein, who pioneered monoclonal antibody technology, has died.

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Small genomes are still shrinking

By | March 27, 2002

genome is still shrinking toward a minimum set of genes necessary for its symbiotic lifestyle.

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Tissue transcriptomes

By | March 27, 2002

In the Early Edition of the Proceedings of the National Academy of Sciences, Andrew Su and collaegues describe high-throughput gene-expression analysis of the mouse and human transcriptomes in different tissues (Proc Natl Acad Sci USA 2002, 10.1073/pnas.012025199).Su etal. performed oligonucleotide hybridisation experiments on samples from 46 human and 45 mouse tissues of diverse origin. They found that 6% of genes are ubiquitously expressed, and individual samples express 30-40% of genes; almos

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Arabidopsis

By | March 26, 2002

Now that the Arabidopsis thaliana genome has been sequenced, plant biologists are turning their efforts to genome annotation. In a 21 March report on the Sciencexpress website, Motoaki Seki and colleagues from the RIKEN Institute in Japan, describe a large-scale analysis of full-length Arabidopsis cDNA libraries (Sciencexpress 2002 10.1126/science.1071006).Seki et al. isolated over 150,000 RIKEN Arabidopsis Full-Length (RAFL) cDNA clones, sequenced the ends and clustered them into almost 15,000

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Europe boosts post genomic research

By | March 26, 2002

25 million to three pan European post genomic projects signals a shift in EU funding of science.

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Hercerptin, shaken not stirred

By | March 26, 2002

Treating tumors with the monoclonal antibody herceptin can bypass drug resistance problems.

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Infectious mechanism in APS

By | March 26, 2002

2-glycoprotein-I may account for the infectious etiology of antiphospholipid syndrome.

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RNAi to RNAi

By | March 26, 2002

An RNA interference (RNAi) screen has been used to find genes involved in RNA interference.

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Early start for new tumor vessels

By | March 25, 2002

Small tumors need blood vessels for growth but it is not clear whether aggregates of malignant cells can induce vascularization or whether these cells grow by co-opting preexisting vessels. In March 15 Journal of Clinical Investigation Peter Vajkoczy and colleagues from University of Heidelberg, Germany, show that new vessels occur as a continuing process of growth and remodeling, starting very early in tumor progression (J Clin Invest 2002, 109:777-785).Vajkoczy et al. used intravital epifluore

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